MEGA-9 [85261-19-4]
Referencia NB-64-10640-1mL
embalaje : 1mLx10mM(inDMSO)
Marca : Neo Biotech
Contact local distributor :
Teléfono : +1 850 650 7790
MEGA-9 (Synonyms: Nonanoyl-N-Methylglucamide)
Catalog No. T20992 Copy Product Info
Purity: 99.9%
MEGA-9 (Nonanoyl-N-Methylglucamide) solubilizes membrane protein and can be used as a nonionic detergent.
MEGA-9
Copy Product InfoSynonyms Nonanoyl-N-Methylglucamide
MEGA-9 (Nonanoyl-N-Methylglucamide) solubilizes membrane protein and can be used as a nonionic detergent.
Cas No. 85261-19-4
Select Batch
Purity:99.9%
Appearance:Solid
Color:White
Contact us for more batch information
Product Introduction
MEGA-9 AI Summary
MEGA-9 exhibits significant antiviral activity against various strains of HIV1, notably inhibiting HIV1 NL4.3 in human MT4 cells with an IC50 of 0.0023 μg/mL and an EC90 of 44.0 ng/mL. It also demonstrates activity against HIV1 3B in human HOS cells (IC50 of 10.0 nM) and other HIV1 strains with EC50 values ranging from 15.0 nM to greater than 200.0 nM. Additionally, it targets the CXCR4 receptor with an IC50 of 13.0 nM, showing low binding affinity for other chemokine receptors. Pharmacokinetically, the compound displays good oral bioavailability in dogs (80.0%), high permeability (86.0 nm/s at pH 7.4), and a moderate stability in human liver microsomes (67.0% at 0.5 μM). Moreover, MEGA-9 interacts with cytochrome P450 enzymes, inhibiting CYP2C19 (20% inhibition), CYP2D6 (IC50 of 1600-1640.0 nM), and CYP3A4 (35% inhibition). It has a high intrinsic clearance rate in rat liver microsomes and is rapidly metabolized and eliminated from the system. In addition to its antiviral properties, MEGA-9 also shows inhibitory effects on human HDAC6 enzyme activity and possesses moderate affinity for the CXCR4 receptor (Ki of 23.0 nM). However, its activity against SARS-CoV-2 and other viral infections appears limited, with low inhibition percentages observed against SARS-CoV-2 induced cytotoxicity. The compound exhibits systemic pharmacokinetic parameters such as changes in Cmax, AUC, and clearance rates when combined with ritonavir, suggesting potential drug-drug interactions. Oral bioavailability in mice is low (2.4%-2.54%), with a maximum plasma concentration of 117.32 nM at an oral dose of 30 mg/kg. These diverse bioactivities and pharmacokinetic properties highlight MEGA-9 as a compound of interest for further drug development and antiviral research..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | MEGA-9 (Nonanoyl-N-Methylglucamide) solubilizes membrane protein and can be used as a nonionic detergent. |
| Synonyms | Nonanoyl-N-Methylglucamide |
| Molecular Weight | 335.44 |
| Formula | C16H33NO6 |
| Cas No. | 85261-19-4 |
| Smiles | CCCCCCCCC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO |
| Relative Density. | 1.172 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||
| Solubility Information | DMSO: 3.36 mg/mL (10.02 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||