MEGA-9 [85261-19-4]

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Cat# NB-64-10640-1mL

Size : 1mLx10mM(inDMSO)

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Phone : +1 850 650 7790

Brand : Neo Biotech

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Contact local distributor :

Phone : +1 850 650 7790

MEGA-9 (Synonyms: Nonanoyl-N-Methylglucamide)

Catalog No. T20992 Copy Product Info

Purity: 99.9%

MEGA-9 (Nonanoyl-N-Methylglucamide) solubilizes membrane protein and can be used as a nonionic detergent.

MEGA-9

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Synonyms Nonanoyl-N-Methylglucamide

MEGA-9 (Nonanoyl-N-Methylglucamide) solubilizes membrane protein and can be used as a nonionic detergent.

Cas No. 85261-19-4

Batch Information

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Purity:99.9%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

MEGA-9 AI Summary

MEGA-9 exhibits significant antiviral activity against various strains of HIV1, notably inhibiting HIV1 NL4.3 in human MT4 cells with an IC50 of 0.0023 μg/mL and an EC90 of 44.0 ng/mL. It also demonstrates activity against HIV1 3B in human HOS cells (IC50 of 10.0 nM) and other HIV1 strains with EC50 values ranging from 15.0 nM to greater than 200.0 nM. Additionally, it targets the CXCR4 receptor with an IC50 of 13.0 nM, showing low binding affinity for other chemokine receptors. Pharmacokinetically, the compound displays good oral bioavailability in dogs (80.0%), high permeability (86.0 nm/s at pH 7.4), and a moderate stability in human liver microsomes (67.0% at 0.5 μM). Moreover, MEGA-9 interacts with cytochrome P450 enzymes, inhibiting CYP2C19 (20% inhibition), CYP2D6 (IC50 of 1600-1640.0 nM), and CYP3A4 (35% inhibition). It has a high intrinsic clearance rate in rat liver microsomes and is rapidly metabolized and eliminated from the system. In addition to its antiviral properties, MEGA-9 also shows inhibitory effects on human HDAC6 enzyme activity and possesses moderate affinity for the CXCR4 receptor (Ki of 23.0 nM). However, its activity against SARS-CoV-2 and other viral infections appears limited, with low inhibition percentages observed against SARS-CoV-2 induced cytotoxicity. The compound exhibits systemic pharmacokinetic parameters such as changes in Cmax, AUC, and clearance rates when combined with ritonavir, suggesting potential drug-drug interactions. Oral bioavailability in mice is low (2.4%-2.54%), with a maximum plasma concentration of 117.32 nM at an oral dose of 30 mg/kg. These diverse bioactivities and pharmacokinetic properties highlight MEGA-9 as a compound of interest for further drug development and antiviral research..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	MEGA-9 (Nonanoyl-N-Methylglucamide) solubilizes membrane protein and can be used as a nonionic detergent.
Synonyms	Nonanoyl-N-Methylglucamide

Chemical Properties

Molecular Weight	335.44
Formula	C₁₆H₃₃NO₆
Cas No.	85261-19-4
Smiles	CCCCCCCCC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
Relative Density.	1.172 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.36 mg/mL (10.02 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9812 mL	14.9058 mL	29.8116 mL	149.0580 mL
5 mM	0.5962 mL	2.9812 mL	5.9623 mL	29.8116 mL
10 mM	0.2981 mL	1.4906 mL	2.9812 mL	14.9058 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.