IL1 beta (IL1B) Mouse Monoclonal Antibody [Clone ID: OTI3E1]
Referencia TA506443
embalaje : 100ul
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IL1 beta (IL1B) Mouse Monoclonal Antibody [Clone ID: OTI3E1]
SKU
TA506443
IL1B mouse monoclonal antibody, clone OTI3E1 (formerly 3E1)
| Product Data | |
| Clone Name | OTI3E1 |
|---|---|
| Application | IF, IHC, WB |
| Recommended Dilution | WB 1:1000~4000, IHC 1:150, IF 1:100 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human IL1B(NP_000567) produced in HEK293T cell. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 30.6 kDa |
| Gene Name | interleukin 1 beta |
| Database Link | |
| Background | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. provided by RefSeq, Jul 2008 |
| Synonyms | IL-1; IL1-BETA; IL1F2 |
| Reference Data | |
| Protein Categories | Allergies and autoimmune diseases, Chemokines, Cytokines, Growth Factors, Intracellular Proteins, Secreated Proteins |
| Protein Families | Druggable Genome, Secreted Protein |
| Protein Pathways | Alzheimer's disease, Apoptosis, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, MAPK signaling pathway, NOD-like receptor signaling pathway, Prion diseases, Toll-like receptor signaling pathway, Type I diabetes mellitus |
| Product Manuals |
| FAQs |
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| SDS |
| Antibody Resources |
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| SKU | Description | Size | ||
|---|---|---|---|---|
| CF506443 | Carrier-free (BSA/glycerol-free) IL1B mouse monoclonal antibody, clone OTI3E1 (formerly 3E1) | 100 ug | | |
| TA506443AM | IL1B mouse monoclonal antibody,clone 3E1, Biotinylated | 100 ul | | |
| TA506443BM | IL1B mouse monoclonal antibody,clone 3E1, HRP conjugated | 100 ul | | |
| TA506443S | IL1B mouse monoclonal antibody, clone OTI3E1 (formerly 3E1) | 30 ul | | |
Citations
IL-1beta expressing neutrophil extracellular traps in Legionella pneumophila infection
Koutantou, Konstantinidis, Chochlakis et al
Front Immunol (2025) 16, 1573151 DOI: 10.3389/fimmu.2025.1573151
Koutantou, Konstantinidis, Chochlakis et al
Front Immunol (2025) 16, 1573151 DOI: 10.3389/fimmu.2025.1573151
Cited by 3
AI Summary: In this study, the mouse anti-IL-1β antibody from OriGene was used to detect IL-1β on neutrophil extracellular traps, helping to elucidate the role of IL-1β in immune responses during Legionella pneumophila infection.
Snippet: anti-citrullinated H3 (R2+R8+R17) (1/500 dilution;Abcam) polyclonal Ab, a goat anti-myeloperoxidase (MPO)-specific mAb (1/150 dilution;R&D systems) and a mouse anti-IL-1β antibody (1/200 dilution;OriGene). A donkey anti-goat IgG (H+L) antibody conjugated to a fluorophore with an emission peak at 647 nm (1/500;Biotium), a donkey anti-rabbit IgG (H+L) antibody conjugated to a fluorophore with a
Gαq-PKD/PKCμ signal regulating the nuclear export of HDAC5 to induce the IκB expression and limit the NF-κB-mediated inflammatory response essential for early pregnancy
Jiang, He, Liu et al
Elife (2023) 12 DOI: 10.7554/eLife.83083
Jiang, He, Liu et al
Elife (2023) 12 DOI: 10.7554/eLife.83083
AI Summary: OriGene’s mouse monoclonal antibody against IL-1β (Cat# TA506443) was used in this study to detect IL-1β protein levels, contributing to the analysis of inflammatory responses during decidualization.
Snippet: d in 5% skimmed milk (BD) and probed with rabbit polyclonal antibody against Gαq, rabbit monoclonal antibody against IGFBP-1 (Abcam, Cat# ab181141, 1:1000), mouse monoclonal antibody against IL-1β (Origene Inc, Cat# TA506443, 1:1000), rabbit polyclonal antibody against p65 (Abcam, Cat# ab32536, 1:1000), rabbit polyclonal antibody against p50 (Abcam Cat# ab32360, 1:1000), p-STAT3 (Abcam Cat# ab76
Neutrophil extracellular traps in giant cell arteritis biopsies: presentation, localization and co-expression with inflammatory cytokines
Palamidas, Argyropoulou, Georgantzoglou et al
Rheumatology (Oxford) (2021)
Palamidas, Argyropoulou, Georgantzoglou et al
Rheumatology (Oxford) (2021)
Cited by 33
AI Summary: OriGene products contributed to this study by providing mouse monoclonal antibodies against IL-1β (TA506443), IL-6 (TA500067), and IL-17A (TA318811), which were used for immunodetection of these cytokines in tissue samples to assess their co-localization with neutrophil extracellular traps in giant cell arteritis biopsies.
Snippet: For immunodetection of IL-1β, IL-6, IL-17A and CD68 124 (monocytes/macrophages detection) a mouse monoclonal antibody was used (OriGene Technologies Inc.;125 TA506443, TA500067, TA318811 respectively and Agilent;M0876) in 1:200 dilution in combination
Influence of hyperocclusion on the remodeling of gingival tissues
Li, Wang, Liu et al
Int Immunopharmacol (2021) 98, 107885 DOI: 10.1016/j.intimp.2021.107885
Li, Wang, Liu et al
Int Immunopharmacol (2021) 98, 107885 DOI: 10.1016/j.intimp.2021.107885
AI Summary: OriGene products contributed primary antibodies for proliferating cell nuclear antigen (PCNA), p65, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and β-catenin, which were used for immunohistochemical detection of key proteins involved in gingival tissue remodeling in this study.
Snippet: Routine Avidin-Biotin Complex (ABC) staining method was used. The primary antibodies for proliferating cell nuclear antigen (PCNA), P65, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and β-catenin were provided by the Origene Technologies company
Treponema pallidum promotes macrophage polarization and activates the NLRP3 inflammasome pathway to induce interleukin-1β production
Lin, Liu, Zhu et al
BMC Immunol. (2018) 19 (1), 28 DOI: 10.1186/s12865-018-0265-9
Lin, Liu, Zhu et al
BMC Immunol. (2018) 19 (1), 28 DOI: 10.1186/s12865-018-0265-9
AI Summary: In this study, OriGene’s anti-IL-1β antibody was used to detect IL-1β protein levels in macrophages, helping to demonstrate the role of NLRP3 inflammasome activation in response to Treponema pallidum infection.
Snippet: DF membrane for 1 h at 4 °C and 400 mA. After blocking with 5% milk and TBST, the membranes were incubated overnight at 4 °C with the following primary antibodies: anti-IL-1β (1:2000 dilution;Origene Inc., USA), anti-NLRP3 (1:1000 dilution;Abcam Inc., USA), anti-caspase-1 (active caspase-1(P20), 1:2000 dilution;R&D Systems Inc., USA) or anti-β-actin (1:5000 dilution;Abcam Inc., USA). T;... DF memb...
Duhuo Jisheng Decoction inhibits SDF-1-induced inflammation and matrix degradation in human degenerative nucleus pulposus cells in vitro through the CXCR4/NF-κB pathway
Liu, Wang, Huang et al
Acta Pharmacol. Sin. (2018) 39 (6), 912-922 DOI: 10.1038/aps.2018.36
Liu, Wang, Huang et al
Acta Pharmacol. Sin. (2018) 39 (6), 912-922 DOI: 10.1038/aps.2018.36
AI Summary: In this study, the OriGene mouse anti-TNF-α antibody was used to detect TNF-α protein levels, helping to assess the inflammatory response in human degenerative nucleus pulposus cells treated with Duhuo Jisheng Decoction.
Snippet: with primary antibodies rabbit anti-p-p65 and anti-p65 (Cell Signaling Technology, Inc, Beverly, MA, USA), rabbit anti-MMP-3 and anti-MMP-13 (Epitomics), rabbit anti-CXCR4 (Cell Signaling Technology, Inc, Beverly, MA, USA), mouse anti-TNF-α (OriGene, Herford
Showing 1-6 of 8 papers.
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