Azithromycin
Referencia M5438-50mg
embalaje : 50mg
Marca : AbMole Bioscience
CP 62993
Quality Control & Documentation
Biological Activity
Azithromycin is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.
Product Citations
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J Oncol. 2022 Jun 29;2022:1399697.
Mechanism of Targeting the Hedgehog Signaling Pathway against Chemotherapeutic Resistance in Multiple Myeloma
Azithromycin purchased from AbMole
Chemical Information
Molecular Weight | 748.98 |
Formula | C38H72N2O12 |
CAS Number | 83905-01-5 |
Solubility (25°C) | 100 mg/mL in DMSO |
Storage | 2-8°C, dry, protect from light, sealed |
Conversion of different model animals based on BSA (PMID: 27057123)
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
References
[1] Madeleine E Oliver, et al. Azithromycin in viral infections
[2] Anton Firth, et al. Azithromycin: The First Broad-spectrum Therapeutic
[3] Bharat Damle, et al. Clinical Pharmacology Perspectives on the Antiviral Activity of Azithromycin and Use in COVID-19
[4] Ahmed H H Bakheit, et al. Azithromycin
[5] Teresa G Potter, et al. Azithromycin for the treatment of gastroparesis