Azithromycin

Biological Activity

Azithromycin is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.

Product Citations

• 

  J Oncol. 2022 Jun 29;2022:1399697.

  Mechanism of Targeting the Hedgehog Signaling Pathway against Chemotherapeutic Resistance in Multiple Myeloma
  Azithromycin purchased from AbMole

Chemical Information

Molecular Weight	748.98
Formula	C38H72N2O12
CAS Number	83905-01-5
Solubility (25°C)	100 mg/mL in DMSO
Storage	2-8°C, dry, protect from light, sealed

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Madeleine E Oliver, et al. Azithromycin in viral infections

[2] Anton Firth, et al. Azithromycin: The First Broad-spectrum Therapeutic

[3] Bharat Damle, et al. Clinical Pharmacology Perspectives on the Antiviral Activity of Azithromycin and Use in COVID-19

[4] Ahmed H H Bakheit, et al. Azithromycin

[5] Teresa G Potter, et al. Azithromycin for the treatment of gastroparesis