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1-Naphthol [90-15-3]

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Referencia NB-64-01186-1g

embalaje : 1g

Contact local distributor :

Teléfono : +1 850 650 7790

Marca : Neo Biotech

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Teléfono : +1 850 650 7790

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1-Naphthol

(Synonyms: NSC 9586, Nako TRB, Furro ER) Copy Product Info

Synonyms: NSC 9586, Nako TRB, Furro ER

Catalog No. T10023 Copy Product Info

Purity: 98.8%

1-Naphthol (Furro ER) is an excited state proton transfer (ESPT) fluorescent molecular probe for sensing thermotropic microenvironmental changes of pluronic F127 in aqueous media.

Cas No. 90-15-3

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.8%

Appearance:Solid

Color:White

Product Introduction

1-Naphthol AI Summary

1-Naphthol exhibits a range of bioactivities, including inhibition of 5-lipoxygenase in rat basophilic leukemia cells (IC50 = 3600 nM), prostaglandin G/H synthase in BSV cell lines (IC50 = 2000 nM), and significant inhibition of mouse arachidonic acid-induced ear edema (59% inhibition at 100 μg/ear). It also demonstrates inhibitory activity against various cytochrome P450 enzymes, specifically human CYP1A2 (IC50 = 3200 nM), human CYP2A6 (IC50 = 130,000 nM), and mouse CYP2A5 (IC50 = 140,000 nM). Moderate lipophilicity is suggested by a log PNalk value of 0.55 and a LogD7.4 value of 2.5, indicating potential good membrane permeability and cellular uptake. It has been evaluated for anti-plasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 with an IC50 value of 56,510 nM. 1-Naphthol also demonstrates some level of interaction with UDP-glucuronosyltransferase (UGT) enzymes, showing significant activity with UGT1A1, UGT1A6, UGT1A8, and UGT2A1 but minimal to no activity with several other UGT enzymes. Its solubility has been reported as 1050 μg/mL and 1500 μg/mL in water in different assessments. It weakly inhibits human recombinant UGT1A1 with an IC50 of 280,000 nM for estradiol 3-glucuronidation and 240,000 nM for bilirubin glucuronidation. Additionally, it shows weak cytotoxicity in human K562 cells with an IC50 value greater than 100,000 nM and inhibits Mycobacterium tuberculosis IMPDH deltaCBS mutant with a 68% reduction in NADH production at 1 mM concentration. Overall, 1-Naphthol exhibits diverse bioactivity with specific moderate inhibitory effects on certain enzymes and cellular processes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1-Naphthol (Furro ER) is an excited state proton transfer (ESPT) fluorescent molecular probe for sensing thermotropic microenvironmental changes of pluronic F127 in aqueous media.
Synonyms	NSC 9586, Nako TRB, Furro ER

Chemical Properties

Molecular Weight	144.17
Formula	C₁₀H₈O
Cas No.	90-15-3
Smiles	OC1=CC=CC2=CC=CC=C12
Relative Density.	1.224 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (416.18 mM), Sonication is recommended.

H2O: 1 mg/mL (6.94 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	6.9363 mL	34.6813 mL	69.3626 mL	346.8128 mL
5 mM	1.3873 mL	6.9363 mL	13.8725 mL	69.3626 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.6936 mL	3.4681 mL	6.9363 mL	34.6813 mL
20 mM	0.3468 mL	1.7341 mL	3.4681 mL	17.3406 mL
50 mM	0.1387 mL	0.6936 mL	1.3873 mL	6.9363 mL
100 mM	0.0694 mL	0.3468 mL	0.6936 mL	3.4681 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

NSC-9586NSC9586InhibitorinhibitHuman Endogenous MetaboliteEndogenousMetaboliteEndogenous Metabolite1-Naphthol1Naphthol1 Naphthol

Related Tags: 1-Naphthol chemical structure | 1-Naphthol formula | 1-Naphthol molecular weight

1-Naphthol [90-15-3]

Referencia NB-64-01186-1g

Contact local distributor :

Marca : Neo Biotech

Contact local distributor :

1-Naphthol

Product Introduction

Calculator

In Vivo Formulation Calculator (Clear solution)

Dose Conversion

Keywords

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