1-Naphthol [90-15-3]
Referência NB-64-01186-1g
Tamanho : 1g
Marca : Neo Biotech
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Telefone : +1 850 650 7790
1-Naphthol (Synonyms: NSC 9586, Nako TRB, Furro ER)
Catalog No. T10023 Copy Product Info
Purity: 98.8%
1-Naphthol (Furro ER) is an excited state proton transfer (ESPT) fluorescent molecular probe for sensing thermotropic microenvironmental changes of pluronic F127 in aqueous media.
1-Naphthol
Copy Product InfoSynonyms NSC 9586, Nako TRB, Furro ER
1-Naphthol (Furro ER) is an excited state proton transfer (ESPT) fluorescent molecular probe for sensing thermotropic microenvironmental changes of pluronic F127 in aqueous media.
Cas No. 90-15-3
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Purity:98.8%
Appearance:Solid
Color:White
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Product Introduction
1-Naphthol AI Summary
1-Naphthol exhibits a range of bioactivities, including inhibition of 5-lipoxygenase in rat basophilic leukemia cells (IC50 = 3600 nM), prostaglandin G/H synthase in BSV cell lines (IC50 = 2000 nM), and significant inhibition of mouse arachidonic acid-induced ear edema (59% inhibition at 100 μg/ear). It also demonstrates inhibitory activity against various cytochrome P450 enzymes, specifically human CYP1A2 (IC50 = 3200 nM), human CYP2A6 (IC50 = 130,000 nM), and mouse CYP2A5 (IC50 = 140,000 nM). Moderate lipophilicity is suggested by a log PNalk value of 0.55 and a LogD7.4 value of 2.5, indicating potential good membrane permeability and cellular uptake. It has been evaluated for anti-plasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 with an IC50 value of 56,510 nM. 1-Naphthol also demonstrates some level of interaction with UDP-glucuronosyltransferase (UGT) enzymes, showing significant activity with UGT1A1, UGT1A6, UGT1A8, and UGT2A1 but minimal to no activity with several other UGT enzymes. Its solubility has been reported as 1050 μg/mL and 1500 μg/mL in water in different assessments. It weakly inhibits human recombinant UGT1A1 with an IC50 of 280,000 nM for estradiol 3-glucuronidation and 240,000 nM for bilirubin glucuronidation. Additionally, it shows weak cytotoxicity in human K562 cells with an IC50 value greater than 100,000 nM and inhibits Mycobacterium tuberculosis IMPDH deltaCBS mutant with a 68% reduction in NADH production at 1 mM concentration. Overall, 1-Naphthol exhibits diverse bioactivity with specific moderate inhibitory effects on certain enzymes and cellular processes..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 1-Naphthol (Furro ER) is an excited state proton transfer (ESPT) fluorescent molecular probe for sensing thermotropic microenvironmental changes of pluronic F127 in aqueous media. |
| Synonyms | NSC 9586, Nako TRB, Furro ER |
| Molecular Weight | 144.17 |
| Formula | C10H8O |
| Cas No. | 90-15-3 |
| Smiles | OC1=CC=CC2=CC=CC=C12 |
| Relative Density. | 1.224 g/cm3 |
| Storage | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (416.18 mM), Sonication is recommended.  H2O: 1 mg/mL (6.94 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||||||||||||
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