Cholesterol sulfate [1256-86-6]

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Cat# NB-64-130497-50mg

Size : 50mg

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Brand : Neo Biotech

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Phone : +1 850 650 7790

Cholesterol sulfate (Synonyms: Cholesterol 3-sulfate)

Catalog No. TN8971 Copy Product Info

Purity: 97%

Cholesterol sulfate is a multifunctional endogenous sterol sulfate and selective DOCK2 inhibitor with an IC50 of 2 μM in mouse assays. Cholesterol sulfate plays multiple roles including in epidermal barrier formation by regulating keratinocyte differentiation and corneocyte desquamation, functions as a serine-protease inhibitor, acts as a glucocorticoid receptor antagonist, and activates RORα/γ in the thymus. Cholesterol sulfate serves as a critical research tool for investigating cutaneous biology, immunomodulation, steroid metabolism, sperm capacitation, platelet aggregation, and disorders such as X-linked ichthyosis.

Cholesterol sulfate

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Synonyms Cholesterol 3-sulfate

Cas No. 1256-86-6

Batch Information

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Purity:97%

Appearance:Solid

Color:White

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COA HNMR MS

Product Introduction

Bioactivity

Description	Cholesterol sulfate is a multifunctional endogenous sterol sulfate and selective DOCK2 inhibitor with an IC50 of 2 μM in mouse assays. Cholesterol sulfate plays multiple roles including in epidermal barrier formation by regulating keratinocyte differentiation and corneocyte desquamation, functions as a serine-protease inhibitor, acts as a glucocorticoid receptor antagonist, and activates RORα/γ in the thymus. Cholesterol sulfate serves as a critical research tool for investigating cutaneous biology, immunomodulation, steroid metabolism, sperm capacitation, platelet aggregation, and disorders such as X-linked ichthyosis.
Targets&IC50	DOCK2 (mouse):2 μM
Synonyms	Cholesterol 3-sulfate

Chemical Properties

Molecular Weight	466.72
Formula	C₂₇H₄₆O₄S
Cas No.	1256-86-6
Smiles	C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CCCC(C)C)C)(CC4)01)01)(CC=C1C[C@@H](OS(=O)(=O)O)CC2)01)01

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (42.85 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1426 mL	10.7131 mL	21.4261 mL	107.1306 mL
5 mM	0.4285 mL	2.1426 mL	4.2852 mL	21.4261 mL
10 mM	0.2143 mL	1.0713 mL	2.1426 mL	10.7131 mL
20 mM	0.1071 mL	0.5357 mL	1.0713 mL	5.3565 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.