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> Cholesterol sulfate [1256-86-6]

Cholesterol sulfate [1256-86-6]

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Referencia NB-64-130497-50mg

embalaje : 50mg

Marca : Neo Biotech

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Cholesterol sulfate (Synonyms: Cholesterol 3-sulfate)

Catalog No. TN8971 Copy Product Info
Purity: 97%
Cholesterol sulfate is a multifunctional endogenous sterol sulfate and selective DOCK2 inhibitor with an IC50 of 2 μM in mouse assays. Cholesterol sulfate plays multiple roles including in epidermal barrier formation by regulating keratinocyte differentiation and corneocyte desquamation, functions as a serine-protease inhibitor, acts as a glucocorticoid receptor antagonist, and activates RORα/γ in the thymus. Cholesterol sulfate serves as a critical research tool for investigating cutaneous biology, immunomodulation, steroid metabolism, sperm capacitation, platelet aggregation, and disorders such as X-linked ichthyosis.

Cholesterol sulfate

Copy Product Info
Synonyms Cholesterol 3-sulfate

Cholesterol sulfate is a multifunctional endogenous sterol sulfate and selective DOCK2 inhibitor with an IC50 of 2 μM in mouse assays. Cholesterol sulfate plays multiple roles including in epidermal barrier formation by regulating keratinocyte differentiation and corneocyte desquamation, functions as a serine-protease inhibitor, acts as a glucocorticoid receptor antagonist, and activates RORα/γ in the thymus. Cholesterol sulfate serves as a critical research tool for investigating cutaneous biology, immunomodulation, steroid metabolism, sperm capacitation, platelet aggregation, and disorders such as X-linked ichthyosis.

Cholesterol sulfate
Cas No. 1256-86-6
Other Forms of Cholesterol sulfate:
Cholesteryl sulfate sodiumT52392864-50-8
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Purity:97%
Appearance:Solid
Color:White
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COA HNMR MS

Product Introduction
Bioactivity
Description
Cholesterol sulfate is a multifunctional endogenous sterol sulfate and selective DOCK2 inhibitor with an IC50 of 2 μM in mouse assays. Cholesterol sulfate plays multiple roles including in epidermal barrier formation by regulating keratinocyte differentiation and corneocyte desquamation, functions as a serine-protease inhibitor, acts as a glucocorticoid receptor antagonist, and activates RORα/γ in the thymus. Cholesterol sulfate serves as a critical research tool for investigating cutaneous biology, immunomodulation, steroid metabolism, sperm capacitation, platelet aggregation, and disorders such as X-linked ichthyosis.
Targets&IC50
DOCK2 (mouse):2 μM
SynonymsCholesterol 3-sulfate
Chemical Properties
Molecular Weight466.72
FormulaC27H46O4S
Cas No.1256-86-6
SmilesC[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CCCC(C)C)C)(CC4)02)02)(CC=C1C[C@@H](OS(=O)(=O)O)CC2)02)02
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 20 mg/mL (42.85 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1426 mL10.7131 mL21.4261 mL107.1306 mL
5 mM0.4285 mL2.1426 mL4.2852 mL21.4261 mL
10 mM0.2143 mL1.0713 mL2.1426 mL10.7131 mL
20 mM0.1071 mL0.5357 mL1.0713 mL5.3565 mL
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.