Whole blood diabetes samples are research biospecimens containing erythrocytes, leukocytes, platelets, and plasma, enabling investigation of cellular, molecular, and metabolic alterations associated with diabetes mellitus. Whole blood has been used in diabetes biomarker research, metabolomics, transcriptomics, molecular profiling, and studies of diabetes-associated complications. Research has shown that whole-blood metabolomic profiles can distinguish individuals with type 2 diabetes and identify metabolic signatures associated with diabetic kidney disease, while whole-blood transcriptomic analyses can identify gene-expression patterns associated with diabetes and altered metabolic pathways.

Key Features

• Whole blood containing multiple cellular and circulating components.

• Samples from diabetes mellitus, including type 1 and/or type 2 diabetes, depending on the cohort.

• Suitable for selected metabolomic, transcriptomic, proteomic, and biomarker analyses, depending on sample collection and processing.

• Clinical and metabolic parameters such as glucose and HbA1c may be available, depending on the collection.

Usual Research Applications

• Diabetes biomarker discovery and validation.

• Whole-blood metabolomics and transcriptomics.

• Investigation of insulin resistance and glucose metabolism.

• Research into diabetic kidney disease, diabetic retinopathy, cardiovascular complications, and other diabetes-associated complications.

• Investigation of molecular changes associated with antidiabetic treatment.