SARS-CoV-2 - Telmisartan - Therapeutic Candidates

SARS-CoV-2 - Telmisartan - Therapeutic Candidates


Telmisartan is an angiotensin II inhibitor. It blocks the action of angiotensin II through its antagonistic function on the receptors for this substance naturally present in the body, which causes contraction of the arteries and increases arterial pressure. Telmisartan is therefore an antihypertensive drug used in the treatment of high blood pressure and chronic renal failure. Telmisartan has several advantages: its half-life is 24 hours (longer than other angiotensin II receptor antagonists) and it does not alter the metabolism of bradykinin (unlike ACE inhibitors), which avoids associated side effects such as coughing.
Studies have shown that during SARS-Cov-6 infection, alveolar cell ACE2 protein is targeted. The loss of the enzymatic action of ACE2 leads to an increase in the concentration of angiotensin II. This would be the starting point for the cytokine storm described in the most affected Covid-19 patients. For this reason, clinical studies have been initiated to test the effect of telmisartan on the development of acute respiratory distress syndrome (ARDS) in Covid-19 patients.

Cat#
Description
Size
Price Excl. VAT
HY-13955-100mg
 100mg 
HY-13955-50mg
 50mg 
HY-13955-S
 0,5-1mg 
HY-13955-1mL
 10mM/1mL 
HY-13955-500mg
 500mg 
HY-13955-1g
 1g 
289946-1mg
 1mg 
289946-2mg
 2mg 
T017001-10mg
 10mg 
289946-10mg
 10mg 
T017001-1mg
 1mg 
289946-25mg
 25mg 
289946-5mg
 5mg 
T017035-100mg
 100mg 
T017035-10mg
 10mg 
T017045-100mg
 100mg 
T017045-10mg
 10mg 
T017050-100mg
 100mg 
T017050-10mg
 10mg 
445875-100mg
 100mg 
445876-2,5mg
 2.5mg 
294898-10mg
 10mg 
294898-25mg
 25mg 
M3289-100mg
 100 mg 
S1570-100mg
 100mg 
S1570-50mg
 50mg 
AOB1652-10
 10mg 
AOB1652-100
 100mg 
AOB1652-25
 25mg 
A10905-10mM-D
 10mM*1mLinDMSO 
AOB1652-5
 5mg 
AOB1652-50
 50mg 
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