Human bone marrow is a complex hematopoietic tissue containing hematopoietic stem and progenitor cells (HSPCs), developing and mature blood-cell populations, and a heterogeneous stromal microenvironment. It provides an important research model for investigating hematopoiesis, hematopoietic stem cells (HSCs), bone marrow niches, immune-cell development, and hematological disorders. HSC function is regulated by interactions with perivascular and other stromal populations, endothelial cells, osteogenic cells, megakaryocytes, extracellular matrix components, and soluble signaling factors within the bone marrow microenvironment.

Human bone marrow is also a source of bone marrow-derived mesenchymal stromal cells (MSCs), which contribute to the organization and function of the bone marrow microenvironment and support hematopoiesis. These cells can be isolated and expanded ex vivo for in-vitro studies.

Key Features

• Source of human HSCs, HSPCs, and diverse hematopoietic cell populations.

• Contains heterogeneous stromal and niche-associated cell populations.

• Supports studies of hematopoiesis and bone marrow microenvironment biology.

• Source of bone marrow-derived mesenchymal stromal cells (MSCs).

Typical Research Uses

• HSC/HSPC biology and differentiation studies.

• Hematopoiesis and immune-cell research.

• Bone marrow niche and cell–cell interaction studies.

• Hematological disease and leukemia research.

• Isolation, characterization, and expansion of bone marrow-derived MSCs.

• Regenerative medicine and cell-based research.