Angiopoietin-like protein 3 (ANGPTL3) is a secreted glycoprotein predominantly expressed in the liver, playing a pivotal role in lipid metabolism and angiogenesis. Structurally related to the angiopoietin family, ANGPTL3 contains a coiled-coil domain and a fibrinogen-like domain but does not bind to the Tie receptor family. It is a key regulator of plasma lipid levels by inhibiting lipoprotein lipase and endothelial lipase, thus influencing triglyceride and cholesterol metabolism. Dysregulation of ANGPTL3 is implicated in hyperlipidemia, cardiovascular disease, and metabolic disorders, making it a significant biomarker and therapeutic target. Quantitative measurement of ANGPTL3 in biological samples is essential for understanding its physiological and pathological roles.

Performance Characteristics

• Sensitivity: Kits demonstrate high sensitivity, with detection at low concentration.
• Detection Range: Most kits cover a broad dynamic range suitable for physiological and pathological sample concentrations.
• Sample Types: Compatible with human serum, plasma (EDTA, heparin), and cell culture supernatants.
• Assay Time: Rapid protocols allow completion within 90 minutes to 4.5 hours.
• Specificity: Minimal cross-reactivity with other angiopoietin-like proteins or cytokines ensures accurate ANGPTL3 measurement.

Applications

• Clinical Research: Monitoring ANGPTL3 levels in patients with dyslipidemia, cardiovascular diseases, and metabolic syndrome.
• Pharmacological Studies: Evaluating the effects of lipid-lowering drugs and ANGPTL3 inhibitors.
• Basic Research: Investigating ANGPTL3’s role in lipid metabolism, angiogenesis, and liver function.
• Biomarker Discovery: Assessing ANGPTL3 as a diagnostic or prognostic biomarker for cardiovascular risk.

ANGPTL3 assay kits provide reliable, sensitive, and specific tools for the quantitative detection of ANGPTL3 in biological samples. These kits support a wide range of research and clinical applications focused on lipid metabolism and cardiovascular health. Their robust design and ease of use make them indispensable for advancing understanding of ANGPTL3 biology and its therapeutic potential.