1. In obese mice, periodontitis caused the downregulation of MMP2, and upregulation of TIMP1 and TGF-beta1 at transcriptional and translational levels.
2. In the initial periods of AP progression, an increased expression of MMP9 in the TLR2 KO and MyD88 KO mice was observed. In the final periods of AP progression, a reduction of MMP2 expression and an increase of MMP9 expression in the TLR2 KO mice were observed. MMP2 and MMP9 production was modulated for TLR2 and MyD88 during apical periodontitis progression
3. Diet and exercise affect atheromatous MMP2/9 activity by modulating the systemic inflammatory milieu, with sVCAM-1, resistin, and adiponectin closely interacting with each other and with visceral fat.
4. calpains inhibition plays crucial roles in vascular restenosis by preventing neointimal hyperplasia at the early stage via suppression of the MMP2/TGF-beta1 pathway.
5. Aneurysmal-prone factors induced HIF-1alpha can cause overexpression of MMP-2 and MMP-9 and promote aneurysmal progression.
6. These studies illustrated an important role of MMP2 in cognitive and motor behaviors and confirm its importance in NPC activities crucial to brain development, growth and response to and recovery from injury.
7. Secretagogin-dependent MMP2 release from neurons regulates neuroblast migration.
8. This novel mouse model will be a very useful tool for evaluating the mechanistic pathways and for development of novel therapies in cigarette smoke-associated lung emphysema.
9. matrix metalloproteinase 2 (Mmp2) transcript is a target of miR-195a-3p, and that silencing Mmp2 phenocopied the reduced proliferation and migration of MSCs. The therapeutic potential of miR-195a-3p as an angiogenesis inhibitor was also demonstrated in a laser-induced choroidal neovascularization mouse model.
10. developed a novel selective radiolabeled MMP2/9 inhibitor, suitable for single photon emission computed tomography (SPECT) imaging that effectively targets atherosclerotic lesions in mice
11. MMP-2 and MMP-9 have roles in early stages of experimental autoimmune encephalomyelitis induction; MMP-9 from an immune cell source is required in EAE for initial infiltration of leukocytes into the central nervous system
12. This study illustrated that tumour-derived MMP2 has at least two roles in tumour malignancy; to enhance tumour invasiveness by degrading the extracellular matrix and to enhance tumour growth by promoting vessel maturation and function.
13. MMP-2 and -9 expression were suppressed significantly by treatment with SB-3CT. The data demonstrated, for the first time, that SB-3CT strongly reduced corneal lymphangiogenesis and macrophage infiltration during inflammation.
14. animals were submitted to the evaluation of Blood-Brain Barrier permeability and MMP-2 and MMP-9 in striatum, hippocampus and cerebral cortex
15. High MMP2 expression is associated with abdominal aortic aneurysm.
16. Low MMP2 expression is associated with liver fibrosis.
17. Cleavage of beta-DG still occurred when both MMP-2 and MMP-9 were knocked out in gamma - sarcoglycan-deficient mice. The study found that up-regulation of MMP-14 is capable of cleaving beta-DG, and it may be involved in the pathogenesis of sarcoglycanopathy.
18. NH2-terminal truncated MMP-2 "primes" the kidney to enhanced susceptibility to I-R injury via induction of mitochondrial dysfunction.
19. Study demonstrated evidence of beta-dystroglycan cleavage by matrix metalloproteinase-2/-9 in permanent middle cerebral artery occlusion mouse brains; this cleavage was implicated in aquaporin-4 redistribution and brain edema in cerebral ischemia.
20. These results indicate that increased MMP2 and MMP9 activity in the brains of mouse adenovirus type 1-infected susceptible mice may be due to MMP activity produced by endothelial cells, astrocytes, and microglia, which in turn may contribute to blood-brain barrier disruption and encephalitis in susceptible mice.
21. Studies define a novel HMGA1-MMP-2 pathway involved in a subset of human carcinosarcomas and tumor progression in murine models.
22. activation of astrocyte MMP2/JNK1/2 contributes to the pathogenesis of pain hypersensitivity in the complex regional pain syndrome model
23. Ceramide 1-phosphate -stimulated macrophage migration is a receptor mediated effect, and point to MMP-2 and -9 as possible therapeutic targets to control inflammation.
24. MMP-2 potentiates shear-induced platelet activation by enhancing thrombus formation
25. Identify novel MMP-2/cardiac sPLA2 pathway that endows the heart with important endocrine functions, including regulation of inflammation and lipid metabolism in the liver.
26. 129/SvEv mice are more susceptible to abdominal aortic aneurysms compared to C57Bl/6 mice and suggest roles for MMP2/9.
27. Report cross-talk between macrophages, smooth muscle cells, and endothelial cells in response to cigarette smoke alters MMP2/9 levels.
28. MMP-2 silenced hypoxic fibroblasts under hyperglycemic conditions have impaired angiogenic potential. Collagen I/IV secretion is decreased and cell migration is prevented.
29. N-terminal truncated isoform-MMP-2, but not full-length-MMP-2, is the major isoform of MMP-2 involved in skeletal muscle Ischemia-reperfusion injury.
30. These data indicate that oxygen-glucose deprivation-triggered Cav-1 S-nitrosylation interacts with tPA-induced ERK activation to augment MMP2 and 9 secretion and subsequent extracellular matrix degradation.
31. Type IV collagenases, MMP-2 and MMP-9, play important roles in hair cycle, and this could be mediated by induced expression of VEGF, IGF-1, and TGF-beta.
32. Matrix Metalloproteinase-2 Knockout and Heterozygote Mice Are Protected from Hydronephrosis and Kidney Fibrosis after Unilateral Ureteral Obstruction
33. Early MMP-2/MMP-9 activity is not a determinant of long-term recovery after traumatic brain injury in the immature mouse.
34. Taken together, these findings indicate for the first time that AnxA2 phosphorylation and actin remodeling evoked by oxidative stress depend on the sphingolipid pathway, via MMP2 and p38MAPK.
35. Matrix Metalloproteinase-2 (MMP-2) Gene Deletion Enhances MMP-9 Activity, Impairs PARP-1 Degradation, and Exacerbates Hepatic Ischemia and Reperfusion Injury in Mice
36. OPN might be responsible for vascular remodeling diseases associated with hypertension by increasing MMP-2 production in vascluar smooth muscle cells.
37. Further investigation of MMP2 inhibitors of TIMP2/TIMP4 showed an upregulated TIMP2 expression, but not TIMP4. low-dose pre-radiation attenuates the skin inflammation and ROS production induced by medium-dose UV radiation
38. negatively regulates cardiac secreted phospholipase A2 to modulate inflammation and fever
39. Data show that discoidin domain receptor (DDR) 2 siRNA-mediated suppression of extracellular regulated kinase (ERK) 1 and 2 and nuclear factor of kappa B (NF-kappaB) could down-regulate the expressions of matrix metalloproteinase (MMP) 2 and 9.
40. Findings indicate the importance of MMP-2 in central nervous system development and dendritogenesis, and highlight the importance of a correct developmental wiring for adult brain morphology and function.
41. Dietary supplementation with n-3 PUFAs may have protective anti-inflammatory effects mediated through modulation of MMPs and TIMPs
42. Cytokine-induced MMP-2 activity specifically at the inflammatory border collectively act to accelerate leukocyte chemotaxis across the parenchymal border.
43. MMP2/9 expression and activity are elevated in lacrimal glands of two murine models of Sjogren's syndrome, suggesting that manipulation of MMP2/9 activity might be a potential therapeutic target in chronically inflamed lacrimal glands.
44. Data indicate that gelatinase A (MMP-2) deficient embryonic fibroblasts show reduced differentiation into adipocytes.
45. beta-elemene downregulates expression of uPA, uPAR, MMP-2, and MMP-9 in a murine intraocular melanoma model
46. Smoking equivalent levels of nicotine exposure induces VCAM-1, MMP-2, and MMP-9 expression.
47. PDGF-D intensifies fibrogenesis by interfering with the fibrolytic activity of the TIMP-1/MMP-2/MMP-9 system, and PDGF-D signaling is mediated through both PDGF-alpha and -beta receptors.
48. PPARdelta-mediated modulation of MMP-2 secretion and elastin expression may contribute to the maintenance of skin integrity by inhibiting ROS generation
49. Study reveals the dual role of MMP2 in ECM degradation, as well as ECM synthesis in pathogenesis of thoracic aortic aneurysms.
50. In conclusion, ATRA may increase expression of MMP-2 and MMP-9 by the potential signal pathway of RAR-alpha and RAR-gamma in injury podocyte induced by adriamycin, but not RAR-beta.

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