Histamine [51-45-6]
Referência HY-B1204-100mg
Tamanho : 100mg
Marca : MedChemExpress
Contactar o distribuidor local :
Telefone : +1 850 650 7790
| Description |
Histamine is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. |
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| IC50 & Target |
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| Cellular Effect |
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| In Vivo |
Histamine can be used in animal modeling to create gastrointestinal ulcer models. After intravenous injection, the maximum concentration and AUC of histamine in liver and liver tumor tissues are higher than those in subcutaneous tissues[1].
Induction of Gastrointestinal Ulcer[2]
Background
Histamine can cause increased gastric acid secretion, decreased mucus production, reflux of pancreatic juice, poor gastric blood flow, and thus gastric ulcers. Stress can cause increased gastrointestinal motility, making the gastric folds more susceptible to damage when exposed to acid.
Specific Modeling Methods
Guinea Pig: male • albino •
Administration: 5 mg/kg • i.p. • single dose
Note
(1) No eating or drinking is allowed 24 hours before the experiment.
(2) The animals are sacrificed 2 hours after histamine injection, and treated with 1% formalin to check for gastric ulcers. Modeling Indicators
The ulcers were punctate or elongated. After the model was dissected, the ulcer index (the sum of the lengths of the lesions) was measured under a microscope to be 3.4 mm.
Opposite Product(s): Cimetidine (HY-14289)
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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| Essai clinique |
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| Masse moléculaire |
111.15 |
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| Formule |
C5H9N3 |
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| Appearance |
Solid |
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| Color |
White to yellow |
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| SMILES |
NCCC1=CN=CN1 |
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| Initial Source | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Livraison | Room temperature in continental US; may vary elsewhere. |
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| Stockage |
-20°C, stored under nitrogen, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture) |
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| Solvant et solubilité |
In Vitro:
H2O : 125 mg/mL (1124.61 mM; Need ultrasonic) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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| Références |
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