Quimigen Portugal > ANGPTL3 antibody - N-terminal region
ANGPTL3 antibody - N-terminal region
Referência ARP42412_P050
Tamanho : 100ul
Marca : Aviva Systems Biology
ANGPTL3 Antibody - N-terminal region (ARP42412_P050)
| Datasheets/Manuals | Printable datasheet for anti-ANGPTL3 (ARP42412_P050) antibody |
|---|
| Tested Species Reactivity | Human |
|---|---|
| Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Pig, Rabbit, Zebrafish |
| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Application | WB, IHC |
| Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human ANGPTL3 |
| Purification | Affinity Purified |
| Predicted Homology Based on Immunogen Sequence | Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 93%; Zebrafish: 86% |
| Peptide Sequence | Synthetic peptide located within the following region: IFQKLNIFDQSFYDLSLQTSEIKEEEKELRRTTYKLQVKNEEVKNMSLEL |
| Concentration | 0.5 mg/ml |
| Blocking Peptide | For anti-ANGPTL3 (ARP42412_P050) antibody is Catalog # AAP42412 (Previous Catalog # AAPP24758) |
| Enhanced Validation |
| Reference | Kathiresan,S., (2008) Nat. Genet. 40 (2), 189-197 |
|---|---|
| Gene Symbol | ANGPTL3 |
| Gene Full Name | Angiopoietin-like 3 |
| Alias Symbols | ANL3, ANG-5, FHBL2, ANGPT5 |
| NCBI Gene Id | 27329 |
| Protein Name | Angiopoietin-related protein 3 |
| Description of Target | The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors. It is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil dom |
| Uniprot ID | Q9Y5C1 |
| Protein Accession # | NP_055310 |
| Nucleotide Accession # | NM_014495 |
| Protein Size (# AA) | 460 |
| Molecular Weight | 54 kDa |
| Protein Interactions | UBC; ITGAV; ITGB3; ITGA5; |
Protein interactions
| Name | # of Products |
|---|---|
| ITGA5 | 130 |
| ITGAV | 127 |
| ITGB3 | 174 |
Biological pathways
| Name | # of Products |
|---|---|
| Acylglycerol homeostasis | 8 |
| Artery morphogenesis | 48 |
| Cell-matrix adhesion | 263 |
| Cholesterol homeostasis | 162 |
| Cholesterol metabolic process | 142 |
| Fatty acid metabolic process | 69 |
| Glycerol metabolic process | 18 |
| Integrin-mediated signaling pathway | 441 |
| Lipid storage | 30 |
| Negative regulation of lipoprotein lipase activity | 18 |
| Negative regulation of phospholipase activity | 8 |
| Phospholipid catabolic process | 33 |
| Phospholipid homeostasis | 22 |
| Positive regulation of angiogenesis | 241 |
| Positive regulation of cell migration | 287 |
| Positive regulation of lipid catabolic process | 29 |
| Triglyceride homeostasis | 46 |
Biological process
| Name | # of Products |
|---|---|
| Acylglycerol homeostasis | 3 |
| Artery morphogenesis | 29 |
| Cell-matrix adhesion | 66 |
| Cholesterol homeostasis | 56 |
| Cholesterol metabolic process | 72 |
| Fatty acid metabolic process | 78 |
| Glycerol metabolic process | 14 |
| Integrin-mediated signaling pathway | 79 |
| Lipid homeostasis | 19 |
| Lipid storage | 19 |
| Negative regulation of catalytic activity | 25 |
| Negative regulation of lipoprotein lipase activity | 6 |
| Negative regulation of phospholipase activity | 2 |
| Phospholipid catabolic process | 10 |
| Phospholipid homeostasis | 7 |
| Phospholipid metabolic process | 26 |
| Positive regulation of angiogenesis | 97 |
| Positive regulation of cell migration | 150 |
| Positive regulation of lipid catabolic process | 9 |
| Response to hormone stimulus | 59 |
| Signal transduction | 1058 |
| Triglyceride homeostasis | 18 |
Cellular components
| Name | # of Products |
|---|---|
| Extracellular region | 1573 |
| Extracellular space | 884 |
Protein function
| Name | # of Products |
|---|---|
| Cell surface binding | 163 |
| Enzyme inhibitor activity | 51 |
| Growth factor activity | 831 |
| Integrin binding | 463 |
| Phospholipase inhibitor activity | 40 |
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