Tocilizumab [375823-41-9]
Referência HY-P9917-1mg
Tamanho : 1mg
Marca : MedChemExpress
Please arrange your schedule properly.
- United States
- Canada
- United Kingdom
- Australia
- Germany
- France
- Japan
- Korea South
- Switzerland
- Algeria
- Argentina
- Austria
- Belgium
- Brazil
- Chile
- Croatia
- Czech Republic
- Denmark
- Finland
- Hong Kong, China
- Hungary
- India
- Iraq
- Ireland
- Israel
- Italy
- Lebanon
- Luxembourg
- Malaysia
- Mexico
- Morocco
- Netherlands
- New Zealand
- Norway
- Pakistan
- Peru
- Philippines
- Poland
- Portugal
- Qatar
- Russia
- Saudi Arabia
- Serbia
- Singapore
- Slovakia
- Slovenia
- South Africa
- Spain
- Sweden
- Taiwan, China
- Thailand
- Tunisia
- Turkey
- Ukraine
- Macao, China
- Other Countries
Tocilizumab (Synonyms: Anti-Human IL6R, Humanized Antibody)
- Cat. No.: HY-P9917 Pureté: 98.00%
- COA
Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis. Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
Tocilizumab Chemical Structure
CAS No. : 375823-41-9
Size | Prix | Stock | Quantité |
---|---|---|---|
1 mg | USD 280 | En stock | |
5 mg | USD 670 | En stock | |
10 mg | Obtenir un devis | ||
50 mg | Obtenir un devis |
* Veuillez sélectionner la quantité avant d'ajouter des articles.
This product is a controlled substance and not for sale in your territory.
Avis client
Based on 18 publication(s) in Google Scholar
18 Publications Citing Use of MCE Tocilizumab
- •J Biomed Sci. 2022 Nov 24;29(1):101. [Abstract]
- •Cell Death Dis. 2021 Dec 20;13(1):16. [Abstract]
- •Breast Cancer Res. 2023 Apr 17;25(1):43. [Abstract]
- •Immunology. 2023 Apr 17.
- •Phytomedicine. 2023 Jan 11;111:154659. [Abstract]
- •Cell Biol Toxicol. 2021 Oct 25. [Abstract]
- •Sci Rep. 2023 Aug 14;13(1):13231. [Abstract]
- •Biochem Pharmacol. 2023 May 19;213:115618. [Abstract]
- •Carcinogenesis. 2023 Mar 20;bgad013. [Abstract]
- •Sci Rep. 2022 Jan 20;12(1):1075. [Abstract]
- •Endocr Relat Cancer. 2023 Jun 1;ERC-23-0130. [Abstract]
- •Oral Dis. 2023 May 30. [Abstract]
- •Int J Chron Obstruct Pulmon Dis. 2023 Apr 13.
- •Biochem Bioph Res Co. 2023 Feb 19.
- •Toxicol Appl Pharmacol. 2022 Feb 11;115921. [Abstract]
- •SSRN. 2024 Feb 7.
- •Research Square Print. October 3rd, 2022.
- •Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Transmissores de Hematozoários. 2020 Sep.
Activité biologique
Pureté et documentation
Références
Avis client
Description |
Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis[1]. Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease)[4]. |
||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IC50 & Target[1][2] |
|
||||||||||||||||||||||||||||||||
In Vitro |
Tocilizumab (Anti-Human IL6R, Humanized Antibody) (1-100 ng/mL; 24 hours, 48 hours) inhibits the cell proliferation (growth rate) in a dose-dependent manner, growth rate by HACM is reduced almost completely by 100 ng/mL tocilizumab[2]. Tocilizumab (Anti-Human IL6R, Humanized Antibody) (0.001-10,000 μg/ml; 2 days) inhibits Ba/F3-gp130-IL-6R cell proliferation stimulated with hIL-6 with an IC50 of 13.5 ng/ml[1]. Tocilizumab (Anti-Human IL6R, Humanized Antibody) (1 μM; 6 hours) reduces the phosphorylation of STAT3 in vitro consistent with in vivo SAS cells[3]. Tocilizumab (Anti-Human IL6R, Humanized Antibody) (1-5 μM; 24 hours) significantly reduces VEGF mRNA expression in SAS cells with serum-free medium[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[2]
Cell Cytotoxicity Assay[1]
Western Blot Analysis[3]
RT-PCR[3]
|
||||||||||||||||||||||||||||||||
In Vivo |
Tocilizumab (Anti-Human IL6R, Humanized Antibody) (intravenous injection; 1.0 mg/100 μL; twice a week, three weeks) decreases the volume of each metastatic focus in tocilizumab-injected mouse brains[2]. Tocilizumab (Anti-Human IL6R, Humanized Antibody) (intraperitoneal injection;100 μg/mL, every 48 hours; 20days) suppresses OSCC progression and suppresses Tumor Angiogenesis[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
|
||||||||||||||||||||||||||||||||
Essai clinique |
|
||||||||||||||||||||||||||||||||
CAS No. | |||||||||||||||||||||||||||||||||
Appearance |
Liquid |
||||||||||||||||||||||||||||||||
Color |
Colorless to light yellow |
||||||||||||||||||||||||||||||||
SMILES |
[Tocilizumab] |
||||||||||||||||||||||||||||||||
Livraison | Shipping with dry ice. |
||||||||||||||||||||||||||||||||
Stockage |
Please store the product under the recommended conditions in the Certificate of Analysis. |
||||||||||||||||||||||||||||||||
Pureté et documentation |
Purity: 99.67% |
||||||||||||||||||||||||||||||||
Références |
|
Tocilizumab Related Classifications
Calculateur de molarité
Calculateur de dilution
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
-
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
Keywords:
Tocilizumab375823-41-9Anti-Human IL6R, Humanized AntibodyInterleukin RelatedILantibodyIL-6RNeutralizingrheumatoidarthritisSARS-CoV-2coronavirus diseaserespiratory failuredyspnoeaCOVID-19Inhibitorinhibitorinhibit
Vos produits récemment consultés:
Demande en ligne
Your information is safe with us. * Required Fields.
Bulk Inquiry
Inquiry Information
- Nom du produit:
- Tocilizumab
- Cat. No.:
- HY-P9917
- Quantité:
- MCE Japan Authorized Agent: