TET2 Antibody
Referência OACA07738-100UL
Tamanho : 100ul
Marca : Aviva Systems Biology
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| Datasheets/Manuals | Printable datasheet for TET2 Antibody (OACA07738) |
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| Predicted Species Reactivity | Human |
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| Product Format | Liquid |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Conjugation | Unconjugated |
| Application | ELISA|IHC |
| Reconstitution and Storage | -20°C or -80°C |
| Immunogen | Recombinant Human Methylcytosine dioxygenase TET2 protein (1833-2002AA) |
| Purification | Affinity Purified |
| Preservative | 0.02% sodium azide |
| Formulation | PBS with, 50% glycerol, pH7.3. |
| Reference | [1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. Wilson R.K. Nature 434:724-731(2005). [2]"Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A.Cancer Lett. 197:63-68(2003). |
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| Gene Symbol | TET2 |
| Gene Full Name | tet methylcytosine dioxygenase 2 |
| Alias Symbols | IMD75, KIAA1546, MDS, methylcytosine dioxygenase TET2, probable methylcytosine dioxygenase TET2, ten-eleven translocation 2, tet oncogene family member 2. |
| NCBI Gene Id | 54790 |
| Protein Name | Methylcytosine dioxygenase TET2 |
| Description of Target | Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. |
| Uniprot ID | Q6N021 |
| Protein Accession # | NP_001120680 |
| Nucleotide Accession # | NM_001127208 |
