Rosiglitazone maleate [155141-29-0]
Referência NB-64-07318-50mg
Tamanho : 50mg
Marca : Neo Biotech
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Rosiglitazone maleate (Synonyms: BRL 49653C, BRL 49653)
Catalog No. T1622 Copy Product Info
Purity: 99.51%
Rosiglitazone maleate (BRL 49653) is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.
Rosiglitazone maleate
Copy Product InfoSynonyms BRL 49653C, BRL 49653
Rosiglitazone maleate (BRL 49653) is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.
Cas No. 155141-29-0
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Purity:99.51%
Color:White to Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Rosiglitazone maleate (BRL 49653) is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. |
| Targets&IC50 | PPARγ2:100 nM (EC50), PPARγ1:30 nM (EC50), PPARγ:42 nM |
| In vivo | In numerous cell lines, Rosiglitazone has been found to inhibit cholesterol synthesis. It activates the AMP-activated protein kinase (AMPK) complex, which includes the α1 and α2 subunits within the AMPKα subunit, leading to an increase in phosphorylation. |
| Synonyms | BRL 49653C, BRL 49653 |
| Molecular Weight | 473.50 |
| Formula | C22H23N3O7S |
| Cas No. | 155141-29-0 |
| Smiles | C(=C\C(O)=O)\C(O)=O.C(C1SC(=O)NC1=O)C2=CC=C(OCCN(C)C3=CC=CC=N3)C=C2 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 87 mg/mL (183.74 mM), Sonication is recommended. H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.97 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
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