- Specifications
Product Description
Rabbit polyclonal antibody raised against PTGS1.
Immunogen
Sheep PTGS1.
Host
Rabbit
Reactivity
Bovine, Dog, Human, Sheep
Specificity
This antibody is reactive in most mammalian species including, human, ovine, bovine, and canine, weakly with mouse and rat. Detects COX-1 expression for human and sheep while reacting weakly with Cyclooxygenase 2 (COX-2).
Form
Liquid
Recommend Usage
ELISA (1:1000)
Western Blot (1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
Immunohistochemistry
Enzyme-linked Immunoabsorbent Assay
Enzyme Immunoassay
Western Blot
- Gene Info — PTGS1
Entrez GeneID
5742Gene Name
PTGS1
Gene Alias
COX1, COX3, PCOX1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS
Gene Description
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Omim ID
176805Gene Ontology
HyperlinkGene Summary
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. [provided by RefSeq
Other Designations
OTTHUMP00000022052|OTTHUMP00000022053|prostaglandin G/H synthase and cyclooxygenase|prostaglandin-endoperoxide synthase 1
- Interactomes
- Pathways
- Diseases
- Abdominal Pain
- Adenocarcinoma
- Adenoma
- Adenomatous Polyps
- Alzheimer disease
- Asthma
- Atherosclerosis
- Atrophy
- Brain Ischemia
+ View More Disease
- Publication Reference
- Immunofluorescent localization of constitutive and inducible prostaglandin H synthase in ovine astroglia.
Thore CR, Nam MJ, Busija DW.
The Journal of Comparative Neurology 1996 Mar; 367(1):1.
Application：IF, Sheep, Sheep astrocytes.
- Immunofluorescent localization of constitutive and inducible prostaglandin H synthase in ovine astroglia.
PTGS1 polyclonal antibody
Referência PAB13623
Tamanho : 1mL
Marca : Abnova
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