P7C3
P7C3 exerts proneurogenic activity by protecting newborn neurons from apoptosis. Prolonged administration to aged rats impedes neuronal death and preserves cognitive capacity 1. Delays disease progression in G93A-SOD2 mutant mouse model of amyotrophic lateral 2. Blocks MPTP-mediated cell death of dopaminergic neurons in the substantia nigra of adult mice, a model of Parkinson disease 3. Restores hippocampal neurogenesis in a mouse model of Down Syndrome 4. The mechanism of action involves activation of nicotinamide phosphoribosyltransferase (NAMPT) with concomitant increase of intracellular levels of NAD 5. Active in vivo.
-
Product Details
- Physical State: Off-white powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Molecular Mass: 474.2
-
References
1. Pieper, A.A., et al., (2010) Cell, 142 : 39
2. Tesla, T., et al., (2012) Proc. Natl. Acad. Sci. USA, 109 : 17016
3. De Jesus-Cortes, H., et al., (2012) Proc. Natl. Acad. Sci. USA, 109 : 17010
4. Latchney, S.E., et al., (2015) Neurosci. Lett., 591 : 86
5. Wang, G., et al., (2014) Cell, 158 : 1324