ML-SA5 [2418670-70-7]
Referência AOB11116-50
Tamanho : 50mg
Marca : AOBIOUS
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Data sheet
Molecular Formula | C19H24ClN3O4S2 |
Molecular Weight | 457.99 |
CAS Numbers | 2418670-70-7 |
Storage Condition | 0°C (short term), -20°C (long term), desiccated |
Solubility | DMSO |
Purity | 98% by HPLC |
Synonym | ML-SA5; ML SA5; MLSA5 |
IUPAC/Chemical Name | N1-(3-Chloro-2-(piperidin-1-yl)phenyl)-N4,N4-dimethylbenzene-1,4-disulfonamide |
InChl Key | YPPWKTIVYUTTEH-UHFFFAOYSA-N |
InChl Code | InChI=1S/C19H24ClN3O4S2/c1-22(2)29(26,27)16-11-9-15(10-12-16)28(24,25)21-18-8-6-7-17(20)19(18)23-13-4-3-5-14-23/h6-12,21H,3-5,13-14H2,1-2H3 |
SMILES Code | O=S(C1=CC=C(S(=O)(N(C)C)=O)C=C1)(NC2=CC=CC(Cl)=C2N3CCCCC3)=O |
References | Lu et al. Small-molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models, Science Advances 07 Feb 2020: Vol. 6, no. 6, eaaz2736 DOI: 10.1126/sciadv.aaz2736 |
More info
Novel mucolipin 1 (ML1) agonist, inducing lysosomal Ca2+ release, ameliorating muscular dystrophies and activating TFEB to correct lysosomal insufficiency in mdx mice