Mitoquinone mesylate

Biological Activity

Mitoquinone (MitoQ) is a mitochondria-targeted antioxidant. The optimal doses for Mitoquinone (MitoQ) and DecylTPP treatment are selected from dose-response experiments during 4-h cold storage (CS). Mitoquinone (MitoQ) treatment significantly reduces pancreatic oedema and neutrophil infiltration. MitoQ dose-dependently increases serum amylase with an approximate doubling at the higher dose. MitoQ treatment nearly doubles lung MPO activity induced by Caerulein with a significant increase of serum IL-6 levels also evident at 10 mg/kg.

Product Citations

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  Redox Biol. 2021 Feb;39:101786.

  Stat2-Drp1 mediated mitochondrial mass increase is necessary for pro-inflammatory differentiation of macrophages
  Mitoquinone mesylate purchased from AbMole

Customer Product Validations & Biological Datas

	Source	Redox Biol (2020 Oct), Figure 6, Mitoquinone mesylate (Abmole Bioscience)
	Method	Cell culture and treatment
	Cell Lines	BMDMs and PMs
	Concentrations	250 and 500 nM
	Incubation Time	15 min
	Results	Furthermore, inhibition of mitochondrial ROS production with MitoQ abrogated LPS-induced TNF-α and IL-6 expression

Chemical Information

Molecular Weight	678.81
Formula	C38H47O7PS
CAS Number	845959-50-4
Form	Oil
Solubility (25°C)	DMSO: ≥ 18 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] Huang W, et al. Mediators Inflamm. Effects of the mitochondria-targeted antioxidant mitoquinone in murine acute pancreatitis.

[2] Mitchell T, et al. J Pharmacol Exp Ther. The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renal tubular cells and rat kidneys.