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Reagentes e instrumentos para imunologia, biologia celular e biologia molecular.

MBP146-78 [188343-77-3]

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Referência NB-64-41023-1mL

Tamanho : 1mLx10mM(inDMSO)

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Telefone : +1 850 650 7790

Marca : Neo Biotech

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Telefone : +1 850 650 7790

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MBP146-78

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Synonyms:

Catalog No. T7321 Copy Product Info

Purity: 99.33%

MBP146-78 is a potent and selective inhibitor of cGMP-dependent protein kinases (cGMP-dependent protein kinases).

Cas No. 188343-77-3

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.33%

Appearance:Solid

Color:White

Product Information

MBP146-78 AI Summary

MBP146-78 exhibits a range of bioactivities, primarily showcasing potent antiparasitic and antimalarial properties. It demonstrates significant inhibition of Eimeria tenella cGMP-dependent protein kinase with an IC50 value of 0.7 nM and shows effective anticoccidial activity in white leghorn chickens. It also displays antiparasitic activity against Toxoplasma gondii with an IC50 value of 210 nM in human foreskin fibroblasts. In terms of antimalarial activity, MBP146-78 significantly reduces Plasmodium berghei parasite burden in mice and inhibits Plasmodium falciparum protein kinase G with an IC50 of 6.0 nM. Additionally, it decreases infectivity of the sporozoite stage of Plasmodium berghei in human HepG2 cells by more than 90% at 2 µM after 40 hours and exhibits growth inhibition against Plasmodium falciparum with an IC50 of 450 nM. The compound also shows limited antiviral activity against SARS-CoV-2 and marginal antibacterial and antifungal activities against various pathogens. Notably, it has low cytotoxicity with a CC50 value greater than 50 µM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	MBP146-78 is a potent and selective inhibitor of cGMP-dependent protein kinases (cGMP-dependent protein kinases).

Chemical Properties

Molecular Weight	335.4179
Formula	C₂₁H₂₂FN₃
Cas No.	188343-77-3
Smiles	CN1CCC(CC1)C1=CC(=C(N1)C1=CC=C(F)C=C1)C1=CC=NC=C1
Relative Density.	1.164 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 11.53 mg/mL (34.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 1.15 mg/mL (3.43 mM), Suspension.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9814 mL	14.9068 mL	29.8136 mL	149.0678 mL
5 mM	0.5963 mL	2.9814 mL	5.9627 mL	29.8136 mL
10 mM	0.2981 mL	1.4907 mL	2.9814 mL	14.9068 mL
20 mM	0.1491 mL	0.7453 mL	1.4907 mL	7.4534 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

ParasiteMBP146-78MBP-146-78MBP14678MBP146 78InhibitorinhibitcGMP

Related Tags: MBP146-78 chemical structure | MBP146-78 formula | MBP146-78 molecular weight

MBP146-78 [188343-77-3]

Referência NB-64-41023-1mL

Contactar o distribuidor local :

Marca : Neo Biotech

Contactar o distribuidor local :

MBP146-78

Product Information

Calculator

In Vivo Formulation Calculator (Clear solution)

Dose Conversion

Keywords

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