Quimigen Portugal > KRT14 Antibody - FITC Conjugated
KRT14 Antibody - FITC Conjugated
Marca : Aviva Systems Biology
KRT14 Antibody - FITC Conjugated (OASA02684)
| Datasheets/Manuals | Printable datasheet for KRT14 Antibody - FITC Conjugated (OASA02684) |
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| Predicted Species Reactivity | Human |
|---|---|
| Product Format | Liquid. Phosphate buffered saline |
| Clonality | Monoclonal |
| Clone | LL002 |
| Isotype | IgG3 |
| Host | Mouse |
| Conjugation | FITC |
| Application | FC|IF |
| :: | Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant Preservative Stabilisers: 0.09% - Sodium Azide (NaN3) 1% - Bovine Serum Albumin |
| :: | Approx Protein Conc: IgG concentration 0.1mg/ml Buffer Solutions: Phosphate buffered saline |
| Reconstitution and Storage | -20°C |
| Immunogen | Last 15 C-terminal residues of human cytokeratin 14 conjugated to thyroglobulin. |
| Purification | Protein A Purified |
| Predicted Homology Based on Immunogen Sequence | Human |
| Concentration | 0.1 mg/ml |
| Specificity | CYTOKERATIN 14 |
| Application Info | Flow Cytometry(1): Neat - 1/10 (1) Special conditions apply - see (*) |
| Reference | 1. Purkis, P.E. et al. (1990) Antibody markers of basal cells in complex epithelia. J. Cell Sci. 97: 39-50. 2. Lane, E.B. & Alexander, C.M. (1990) Use of keratin antibodies in tumor diagnosis. Semin. Canc. Biol. 1: 165-179. 3. Westzels, R.H.W. et al. (1989) Detection of basement membrane components and basal cell keratin 14 in noninvasive and invasive carcinomas of the breast. Am. J. Pathol. 134: 571-579. 4. Moll, R. et al. (1982) The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell. 31: 11-24. 5. Richardson, G. et al. (2004) CD133, a novel marker for human prostatic epithelial stem cells J. Cell Sci. 117:3539-3545. 6. Holliday, D. et al. (2009) Novel multicellular organotypic models of normal and malignant breast: tools for dissecting the role of the microenvironment in breast cancer progression. Breast Cancer Res. 11: R3 |
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| Gene Symbol | KRT14 |
| Alias Symbols | CK14, cytokeratin 14, EBS3, EBS4, K14, keratin 14, type I, keratin, type I cytoskeletal 14, NFJ. |
| NCBI Gene Id | 3861 |
| Protein Name | Keratin, type I cytoskeletal 14 |
| Description of Target | MOUSE ANTI HUMAN CYTOKERATIN 14:FITC |
| Uniprot ID | P02533 |
| Protein Accession # | NP_000517.2 |
| Protein Size (# AA) | 472 |
Protein interactions
| Name | # of Products |
|---|---|
| APC | 191 |
| DST | 37 |
| KRT5 | 34 |
| PKP1 | 34 |
| POU5F1 | 224 |
| PTEN | 158 |
| SUMO1 | 972 |
| SUMO2 | 442 |
| SUMO3 | 154 |
| TCHP | 39 |
| TRADD | 157 |
| UBC | 7030 |
Biological pathways
| Name | # of Products |
|---|---|
| Epidermis development | 99 |
| Hemidesmosome assembly | 53 |
| Intermediate filament bundle assembly | 9 |
Biological process
| Name | # of Products |
|---|---|
| Cell junction assembly | 63 |
| Epidermis development | 70 |
| Epithelial cell differentiation | 53 |
| Hemidesmosome assembly | 13 |
| Intermediate filament bundle assembly | 6 |
| Response to ionizing radiation | 43 |
| Response to zinc ion | 32 |
Cellular components
| Name | # of Products |
|---|---|
| Cell periphery | 18 |
| Cytoplasm | 4549 |
| Cytosol | 1868 |
| Intermediate filament | 61 |
| Intracellular | 1678 |
| Keratin filament | 26 |
| Mitochondrion | 1154 |
| Nucleolus | 1179 |
| Nucleus | 4914 |
Protein function
| Name | # of Products |
|---|---|
| Protein binding | 12191 |
| Structural constituent of cytoskeleton | 188 |
Diseases
| Name | # of Products |
|---|---|
| Disease mutation | 5332 |
| Ectodermal dysplasia | 86 |
| Epidermolysis bullosa | 59 |
| Palmoplantar keratoderma | 65 |
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