Human CD51 Antibody : PE
Referência OASB01118
Tamanho : 100tests
Marca : Aviva Systems Biology
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Human CD51 Antibody : PE (OASB01118)
| Datasheets/Manuals | Printable datasheet for Human CD51 Antibody : PE (OASB01118) |
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| Tested Species Reactivity | Human |
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| Predicted Species Reactivity | Human |
| Clonality | Monoclonal |
| Clone | 13C2 |
| Isotype | IgG1 |
| Host | Mouse |
| Conjugation | R-PE |
| Application | FC |
| Additional Information | Description: CD51 represents the integrin alphaV chain that associates with integrin beta3 (CD61) to form the CD51/CD61 vitronectin receptor on endothelial cells, certain activated leukocytes, NK cells, macrophages, neutrophils, and platelets. CD51 is the most promiscuous integrin alpha subunit as it can form heterodimers with the beta1 (CD29), beta3 (CD61), beta5, beta6 and beta8 subunits in various tissues. CD51/CD61 acts as an activation-independent receptor for platelet attachment and spreading on vitronectin and other RGD-containing proteins including matrix components. It also mediates leukocyte-endothelial cell adhesion via interaction with CD31. |
| Reconstitution and Storage | Store at 2-8C |
| Immunogen | Cell suspension containing osteoclasts from osteoclastomas |
| Concentration | Lot specific |
| Specificity | CD51 |
| Characterization | To insure lot to lot consistency, each batch of product is tested by flow cytometry and/orimmunohistochemistry to conform with the characteristics of a standard reference reagent. |
| Warning | Reagents contain sodium azide which is very toxic if ingested or inhaled. Avoid contact with skin, eyes, orclothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copiousamounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxichydrazoic acid under acidic conditions. Dilute azide- containing compounds in running water beforediscarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing. |
| Dilution | Flow Cytometry: Purified (UNLB) antibody Fluorescein conjugate R-phycoerythrin conjugate <= 1 ug/106 cells 10 uL/106 cells 10 uL/106 cells |
| Application Info | Flow cytometry, Immunohistochemistry (frozen sections) |
| Other Applications Data | Since applications vary, you should determine the optimum workingdilution of the product that is appropriate for your specific need. |
| Storage | - The purified antibody (UNLB) is supplied as 0.1 mg purified immunoglobulin in 1.0 mL of 100 mMborate buffered saline, pH 8.0. Store at 2- 8 C - The fluorescein (FITC) conjugate is supplied as 100 tests in 1.0 mL of PBS/NaN3. Store at 2- 8 C - The R- phycoerythrin (R- PE) is supplied as 100 tests in 1.0 mL of PBS/NaN3 and a stabilizing agent Store at 2- 8 C. Do not freeze! - Protect conjugated forms from light. Reagents are stable for the period shown on the label if stored asdirected. |
| Reference | 1. Knapp, W., B. Dorken, W.R. GIlks, E.P. Rieber, R.E. Schmidt, H. Stein, A.E.G.K. Von dem Borne, eds. 1989. Leukocyte Typing IV: WhiteCell Differentiation Antigens, Oxford University Press, Oxford 2. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte AntigensFacts Book, 2nd Edition, CD51 Section, Academic Press, New York, p. 271 3. Keiffer, N., and D.R. Phillips. 1990. Annu. Rev. Cell. Biol. 6:329 4. Ginsberg, M.H., D. Xiaoping, T.E. O'Toole, J.C. Loftus, and E.F. Plow. 1993. Thromb. Haemost. 70:87. |
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| Gene Symbol | ITGAV |
| Gene Full Name | Integrin alpha-V |
| Alias Symbols | CD51, MSK8, VNRA, VTNR |
| NCBI Gene Id | 3685; 103217487; 100008956; 281875 |
| Protein Name | integrin alpha-V |
| Description of Target | The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. |
| Uniprot ID | P06756, A0A0D9RJD3, G1TE34, P80746 |
| Protein Accession # | NP_001138471.1 |
| Nucleotide Accession # | NM_001144999.2 |
