Human BTK Antibody : PE (Phospho-Tyr223)
Referência OAAQ00032-10tests
Tamanho : 10Tests
Marca : Aviva Systems Biology
Contactar o distribuidor local :
Telefone : +1 850 650 7790
Human BTK Antibody : PE (Phospho-Tyr223)
Human BTK Antibody : PE (Phospho-Tyr223) (OAAQ00032)
| Datasheets/Manuals | Printable datasheet for OAAQ00032 |
|---|
| Tested Species Reactivity | Human, Mouse |
|---|---|
| Predicted Species Reactivity | Mouse, Rat |
| Product Format | Liquid. 1X PBS, 0.09% NaN3, 0.2% BSA. |
| Clonality | Monoclonal |
| Clone | BtkY223-B4 |
| Isotype | Rabbit IgG1k |
| Host | Rabbit |
| Conjugation | PE: Phycoerythrin |
| Application | FC |
| Reconstitution and Storage | 2-8C |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr223 of human phospho Btk |
| Purification | Protein A+G |
| Target Post-Translational Modification | Phospho-Tyr223 |
| Application Info | For flow cytometric staining, the suggested use of this reagent is 5 uL per million cells or 5 uL per 100 uL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. |
| Reference | Liang, C, Tian D, Ren X, et al. (2018) European Journal of Medicinal Chemistry. 151: 315-326. |
|---|---|
| Gene Symbol | BTK |
| Gene Full Name | Bruton tyrosine kinase |
| Alias Symbols | AT, ATK, BPK, XLA, IMD1, AGMX1, IGHD3, PSCTK1 |
| NCBI Gene Id | 695 |
| Protein Name | tyrosine-protein kinase BTK |
| Description of Target | The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Uniprot ID | Q06187 |
| Protein Accession # | NP_000052.1 |
| Nucleotide Accession # | NM_000061.2 |
