GZMA Recombinant Protein
Referência OPCD08056-10UG
Tamanho : 10ug
Marca : Aviva Systems Biology
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Telefone : +1 850 650 7790
GZMA Recombinant Protein (OPCD08056)
| Datasheets/Manuals | Printable datasheet for GZMA Recombinant Protein (OPCD08056) |
|---|
| Predicted Species Reactivity | Homo sapiens|Human |
|---|---|
| Product Format | Freeze-dried Powder. PBS, pH7.4, containing 5% Trehalose. |
| Host | Yeast |
| Conjugation | Unconjugated |
| Application | Ctrl (+), SDS-PAGE, WB |
| Additional Information | Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method) |
| :: | Residues: Ile29-Val262 |
| :: | Subcellular Location: Secreted |
| Reconstitution and Storage | 2°C to 8°C|-80°C |
| Concentration | 200 ug/mL (prior to lyoph) |
| Purity | > 95% |
| Source | Yeast |
| Tag | N-terminal His Tag |
| Gene Symbol | GZMA |
|---|---|
| Gene Full Name | granzyme A |
| Alias Symbols | CTL tryptase;CTLA3;cytotoxic T-lymphocyte proteinase 1;Cytotoxic T-lymphocyte-associated serine esterase-3;fragmentin-1;granzyme 1;granzyme A;Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine protease);granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3);Granzyme-1;h factor;Hanukah factor serine protease);Hanukkah factor;HF;HFSP. |
| NCBI Gene Id | 3001 |
| Protein Name | Granzyme A |
| Description of Target | Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. |
| Uniprot ID | P12544 |
| Protein Accession # | NP_006135.1 |
| Nucleotide Accession # | NM_006144.3 |
| Protein Size (# AA) | Ile29~Val262 |
| Molecular Weight | 28kDa |
