Fullerene-C60 [99685-96-8]

Fullerene-C60 is a potent free radical scavenger with a wide range of bioactivities that can attenuate liver injury and hepatotoxicity, and improve intestinal flora structure and lipid homeostasis.

Methods: To estimate the accumulation of Fullerene-C60 in leukemic cells and to investigate its phototoxic effects on parental and cisplatin-treated leukemic cells. A stable homogeneous hydrocolloid solution of pristine C60 with an average nanoparticle diameter of 50 nm was used in the experiments. Fluorescently labeled C60 was synthesized by covalently coupling C60 with rhodamine B isothiocyanate.
Results: Confocal microscopy Results showed that leukemic Jurkat cells could efficiently take up Fullerene-C60 from the culture medium. Light-emitting diode light (100 mW cm-2, λ = 420–700 nm) was used to excite the accumulated C60. When leukemic Jurkat cells were exposed to a combination of C60 and visible light treatment, a time-dependent decrease in viability was detected. [1]

DMSO: < 1 mg/mL, insoluble

H2O: < 1 mg/mL, insoluble