FAM20C Antibody - C-terminal region
Referência OAAB01003
Tamanho : 400µl
Marca : Aviva Systems Biology
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FAM20C Antibody - C-terminal region (OAAB01003)
| Datasheets/Manuals | Printable datasheet for FAM20C Antibody - C-terminal region (OAAB01003) |
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| Publications | Gingival proteomics reveals the role of TGF beta and YAP/TAZ signaling in Raine syndrome fibrosis Enamel and dentin in Enamel renal syndrome: A confocal Raman microscopy view Lack of FAM20A, Ectopic Gingival Mineralization and Chondro/Osteogenic Modifications in Enamel Renal Syndrome |
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| Predicted Species Reactivity | Human|Mouse |
| Product Format | Liquid.PBS with 0.09% (W/V) sodium azide. |
| Clonality | Polyclonal |
| Isotype | Rabbit Ig |
| Host | Rabbit |
| Application | IHC-P,WB |
| :: | Cellular Location: Secreted. Golgi apparatus Tissue Location: Widely expressed. |
| Reconstitution and Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | This DMP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 443-471 amino acids from the C-terminal region of human DMP4. |
| Purification | This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Concentration | 0.45 mg/ml |
| Application Info | WB: 1:1000 IHC-P: 1:50~100 |
| Gene Symbol | FAM20C |
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| Gene Full Name | FAM20C golgi associated secretory pathway kinase |
| Alias Symbols | C76981, dentin matrix protein 4, DMP, DMP-4, DMP4, extracellular serine/threonine protein kinase FAM20C, family with sequence similarity 20, member C, G-CK, GEF-CK, Golgi casein kinase, golgi-enriched fraction casein kinase, mKIAA4081, RNS. |
| NCBI Gene Id | 56975|80752 |
| Protein Name | Extracellular serine/threonine protein kinase FAM20C|extracellular serine/threonine protein kinase FAM20C precursor [Homo sapiens] |
| Description of Target | Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (PubMed:26091039). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (PubMed:26091039). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1 (PubMed:22582013, PubMed:25789606). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (PubMed:26091039).|Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22900076, PubMed:22732358, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (By similarity). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (By similarity). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1 (PubMed:25789606). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (By similarity). |
| Uniprot ID | Q5MJS3|Q8IXL6 |
| Protein Accession # | https://www.ncbi.nlm.nih.gov/protein/NP_064608.2 |
| Molecular Weight | 66234 |
