Etoposide [33419-42-0]
Referência HY-13629-200mg
Tamanho : 200mg
Marca : MedChemExpress
Etoposide (VP-16; VP-16-213) est un agent de chimiothérapie anticancéreuse. Etoposide inhibe la topoisomérase II, il peut arrêter ainsi la réplication de l'ADN. Etoposide induit un arrêt du cycle cellulaire, l'apoptose et l'autophagie.
Etoposid (VP-16; VP-16-213) ist ein Anti-Krebs-Chemotherapeutikum. Etoposid hemmt die topoisomerase II und stoppt so die DNA-Replikation. Etoposid induziert Zellzyklus-Arrest, apoptosis und autophagy.
Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy.
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Etoposide Chemical Structure
CAS No. : 33419-42-0
This product is a controlled substance and not for sale in your territory.
Based on 100 publication(s) in Google Scholar
Other Forms of Etoposide:
- Etoposide phosphate In-stock
- Etoposide-13C,d3 Obtenir un devis
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Etoposide purchased from MedChemExpress. Usage Cited in: Oncogene. 2023 Feb 2. [Abstract]
- Etoposide (VP16; 5 mg/kg; s.c.; every two days for 8 days) strongly suppresses tumor growth in mice.
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Etoposide purchased from MedChemExpress. Usage Cited in: J Pharm Pharmacol. 2023 Mar 1;rgad007. [Abstract]
- Irinotecan (CPT11; 20 μM; 48 h) or Etoposide (VP16; 20 μM; 48 h) induces MDA-MB-231 cells cycle arrest significantly.
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Etoposide purchased from MedChemExpress. Usage Cited in: Elife. 2022 May 3;11:e69255. [Abstract]
- BCL6 mRNA expression in Etoposide (ETO)-resistant and -sensitive cells. Cells are treated with Etoposide at their respective 1/2 IC50s for 24 hr.
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Etoposide purchased from MedChemExpress. Usage Cited in: Elife. 2022 May 3;11:e69255. [Abstract]
- Etoposide activated mTOR signaling components in Etoposide-resistant Capan-2 and PANC28 cells. Cells were treated with etoposide at their respective 1/2 IC50s for 6 or 12 hr. A long-term treatment with Etoposide activated mTOR signaling components in ETO-resistant cells. Capan-2 and PANC28 cells are treated with 10 μM Etoposide for 2 or 4 days.
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Etoposide purchased from MedChemExpress. Usage Cited in: Elife. 2022 May 3;11:e69255. [Abstract]
- Cell sensitivity to Etoposide (ETO). Cancer cells are treated with etoposide at gradient concentrations for 48 hr.
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Etoposide purchased from MedChemExpress. Usage Cited in: Elife. 2022 May 3;11:e69255. [Abstract]
- Etoposide induced BCL6 protein expression in a time-dependent manner. ETO-resistant or -sensitive cells are treated with etoposide at their respective 1/4 IC50s for 2, 4, or 6 days.
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Etoposide purchased from MedChemExpress. Usage Cited in: Elife. 2022 May 3;11:e69255. [Abstract]
- STAT1 protein and its phosphorylation levels by immunoblotting analysis. Etoposide (ETO)-resistant and -sensitive cells are treated with Etoposide at their respective 1/2 IC50s for indicated time points.
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Etoposide purchased from MedChemExpress. Usage Cited in: Protein Cell. 2022 Jan;13(1):47-64. [Abstract]
- FISH of telomeres on metaphase spreads to detect chromosome end-to-end fusions in 6 kb-HeLa treated with VP-16. Control (Scr) or cGAS-depleted cells (gcGAS-1, gcGAS-2) are either harvested immediately following treatment (VP-16, 2 μM, 1 h) or released for 4 h (Release 4 h) during mitosis.
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Etoposide purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2021 Mar 12;12(3):265. [Abstract]
- Inhibition of PRDX1 increased the sensitivity of HCT116 cells to Etoposide-induced apoptosis: HCT116 cells infected with lentivirus expressing the indicated shRNAs were treated with 50 μM Etoposide for 0-6 h.
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Etoposide purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2020 Sep 28;7(21):2001364. [Abstract]
- Lnc‐Ip53 attenuated the DNA damage- and oxidation stress-induced p53 acetylation at K382. Cells are incubated with 50 µM Etoposide (Eto) for 5 h.
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Etoposide purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2020 Sep 28;7(21):2001364. [Abstract]
- Lnc‐Ip53 attenuated the DNA damage‐ and oxidation stress‐triggered increase of CDKN1A and PUMA. Cells are incubated with 50 µM Etoposide (Eto) for 6 h.
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Etoposide purchased from MedChemExpress. Usage Cited in: Hepatology. 2020 May;71(5):1660-1677. [Abstract]
- Exposure to Etoposide (Eto), another DNA-damaging agent, induces PDIA3P1 expression, suggesting that PDIA3P1 may be up-regulated by DNA-damaging agents.
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Etoposide purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Jul 25;10(21):9477-9494. [Abstract]
- Fibroblasts and HT-1080 cells are treated with 20 µM Etoposide or DMSO (vehicle group) for 2, 4, 8, 16, 24 and 36 h.
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Etoposide purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Jul 25;10(21):9477-9494. [Abstract]
- When cells are treated with 20 µM Etoposide, an obvious increased green focus of RAD51 is observed in the treated fibroblasts using immunofluorescence (IF) staining.
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Etoposide purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Jul 25;10(21):9477-9494. [Abstract]
- When cells are treated with 20 µM Etoposide or DMSO (vehicle group) for 4 h, western blots (WB) shows elevated expression of γH2AX, a marker of double-strand breaks (DSBs), in the Etoposide group.
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Etoposide purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2020 Nov 6;12(11):e12525. [Abstract]
- Immunoblot of PARP1 cleavage of PeTa cells after 6 days of indicated treatment. Etoposide (10 μM; for 24 h) serves as positive control for apoptosis, and H3 serves as loading control.
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Etoposide purchased from MedChemExpress. Usage Cited in: Aging Cell. 2020 Jul;19(7):e13171. [Abstract]
- RPE p16‐mCherry cells were treated with DMSO, Etoposide (20 μM), H2O2 (200 μM), or serum starved for 24 hr.
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Etoposide purchased from MedChemExpress. Usage Cited in: Leuk Lymphoma. 2018 Jan;59(1):162-170. [Abstract]
- WT1 and caspase-3 protein levels are detected in two primary AML blasts treated with 100 μM Eto for 24 h.
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Etoposide purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2017 Nov 1;408:43-54. [Abstract]
- Western blot analysis of p-p70S6k, p70S6k, p-AKT and AKT after 6 h of treatment with 20 μM RAD001. Levels of p-p70S6k and p-AKT are quantified by densitometric analysis and a corresponding histogram is constructed as relative to p70S6k or AKT and α-tubulin. The lower panel shows a representative Western blot.