CR1 Antibody
Referência OAEE00829
Tamanho : 100tests(T100)
Marca : Aviva Systems Biology
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| Datasheets/Manuals | Printable datasheet for CR1 Antibody |
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| Predicted Species Reactivity | Human|Non-human Primate |
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| Product Format | Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Clonality | Monoclonal |
| Clone | E11 |
| Isotype | IgG1 |
| Host | Mouse |
| Conjugation | R-PE |
| Application | FC |
| Reconstitution and Storage | 2°C to 8°C |
| Immunogen | Acute monocytic leukemia cells and normal blood monocytes |
| Purification | Purified by size-exclusion chromatography |
| Concentration | 10 ul / test |
| Specificity | The mouse monoclonal antibody E11 recognizes CD35 (CR1), a type I glycoprotein expressed on granulocytes, monocytes, B cells, folicular dendritic cells, erythrocytes, NK and T cell subsets, as well as e.g. on glomerulal podocytes. |
| Formulation | PE |
| Storage Buffer | The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent. |
| Reference | Hogg N, Ross GD, Jones DB, Slusarenko M, Walport MJ, Lachmann PJ: Identification of an anti-monocyte monoclonal antibody that is specific for membrane complement receptor type one (CR1). Eur J Immunol. 1984 Mar;14(3):236-43. Leukocyte Typing III., McMichael M.J. et al. (Eds.), Oxford University Press (1987); p.611. Nielsen CH, Pedersen ML, Marquart HV, Prodinger WM, Leslie RG: The role of complement receptors type 1 (CR1, CD35) and 2 (CR2, CD21) in promoting C3 fragment deposition and membrane attack complex formation on normal peripheral human B cells. Eur J Immunol. 2002 May;32(5):1359-67. Kremlitzka M, Polgár A, Fülöp L, Kiss E, Poór G, Erdei A: Complement receptor type 1 (CR1, CD35) is a potent inhibitor of B-cell functions in rheumatoid arthritis patients. Int Immunol. 2012 Sep 7. [Epub ahead of print] |
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| Gene Symbol | CR1 |
| Gene Full Name | complement C3b/C4b receptor 1 (Knops blood group) |
| Alias Symbols | C3-binding protein, C3b/C4b receptor, C3BR, C4BR, CD35, CD35 antigen, complement component (3b/4b) receptor 1 (Knops blood group), complement receptor 1, complement receptor type 1, KN, Knops blood group antigen. |
| NCBI Gene Id | 1378 |
| Protein Name | Complement receptor type 1 |
| Description of Target | Mediates cellular binding of particles and immune complexes that have activated complement. |
| Uniprot ID | P17927 |
| Protein Accession # | NP_000564.2; NP_000642.3 |
| Nucleotide Accession # | NM_000573.3; NM_000651.4 |
