Chicken CD28 Antibody : FITC
Referência OASB02412
Tamanho : 0.5mg
Marca : Aviva Systems Biology
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Chicken CD28 Antibody : FITC (OASB02412)
| Datasheets/Manuals | Printable datasheet for Chicken CD28 Antibody : FITC (OASB02412) |
|---|
| Tested Species Reactivity | Chicken |
|---|---|
| Predicted Species Reactivity | Chicken |
| Product Format | Liquid. Phosphate buffered saline containing 0.1% sodium azide |
| Clonality | Monoclonal |
| Host | Mouse |
| Conjugation | FITC |
| Application | FC, ICC, IHC-F |
| Additional Information | Description: Chicken CD28 antigen is a type I transmembrane monomeric glycoprotein which does not contain the cysteine residues that form disulfide-linked covalent homodimers found in the mammalian counterpart. This may reduce the avidity of binding to individual ligand molecules expected to be present on antigen presenting cells. Peripheral gamma/delta+ T cells are CD28 negative. Monoclonal antibodies against CD28 have a costimulatory effect on T cells stimulated by phorbol myristate acetate (PMA), concanavalin A, or monoclonal antibodies against the avian T cell receptor (TCR). Both V beta1- and V beta2-expressing cells respond equally well to stimulation with anti-CD28 in combination with PMA. These responses are resistant to cyclosporin A but inhibited by herbimycin A suggesting that CD28 employs a signaling pathway at least partly distinct from that triggered by TCR/CD3. The monoclonal antibody AV7 also reacts with turkey CD28 as demonstrated by flow cytometry. |
| Reconstitution and Storage | Store at 2-8C |
| Immunogen | Chicken peripheral blood lymphocytes |
| Concentration | 0.5 mg/mL |
| Specificity | CD28 |
| Gene Symbol | CD28, CD28 |
|---|---|
| NCBI Gene Id | 396249; 100126555 |
| Protein Name | T-cell-specific surface glycoprotein CD28 homolog |
| Uniprot ID | P31043 |
| Protein Accession # | NP_990642.1 |
| Nucleotide Accession # | NM_205311.1 |
