- Specifications
Product Description
Mouse monoclonal antibody raised against native CD38.
Immunogen
Native purified CD38 from human thymocytes in foetus.
Host
Mouse
Theoretical MW (kDa)
45
Reactivity
Human
Specificity
This antibody reacts with CD38 (T10), a 45 KDa type II transmembrane glycoprotein strongly expressed mainly on plasma cells and activated T and B lymphocytes; it is an antigenic marker of lymphoid cells.
Form
Liquid
Conjugation
PerCP
Isotype
IgG1
Recommend Usage
Flow Cytometry (10 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
Flow Cytometry
- Gene Info — CD38
Entrez GeneID
952Gene Name
CD38
Gene Alias
T10
Gene Description
CD38 molecule
Omim ID
107270Gene Ontology
HyperlinkGene Summary
CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling. [provided by RefSeq
Other Designations
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase|CD38 antigen|CD38 antigen (p45)|cyclic ADP-ribose hydrolase
- Interactomes
- Pathways
- Diseases
- Publication Reference
- Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction.
Partida-Sanchez S, Gasser A, Fliegert R, Siebrands CC, Dammermann W, Shi G, Mousseau BJ, Sumoza-Toledo A, Bhagat H, Walseth TF, Guse AH, Lund FE.
Journal of Immunology 2007 Dec; 179(11):7827.
- CD38 induces apoptosis of a murine pro-B leukemic cell line by a tyrosine kinase-dependent but ADP-ribosyl cyclase- and NAD glycohydrolase-independent mechanism.
Lund FE, Muller-Steffner H, Romero-Ramirez H, Moreno-Garcia ME, Partida-Sanchez S, Makris M, Oppenheimer NJ, Santos-Argumedo L, Schuber F.
International Immunology 2006 May; 18(7):1029.
- Kinetic competence of the cADP-ribose-CD38 complex as an intermediate in the CD38/NAD+ glycohydrolase-catalysed reactions: implication for CD38 signalling.
Cakir-Kiefer C, Muller-Steffner H, Oppenheimer N, Schuber F.
The Biochemical Journal 2001 Sep; 358(Pt 2):399.
- Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction.
CD38 monoclonal antibody, clone HIT2 (PerCP)
Referência MAB5072
Tamanho : 100Reactions
Marca : Abnova
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Telefone : +1 850 650 7790