Calcitriol [32222-06-3]

Biological Activity

Calcitriol is an Active metabolite of vitamin D3 that activates the vitamin D receptor. Calcitriol (also called 1,25-dihydroxyvitamin D3) is synthesized from 7-dehydrocholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin. Calcitriol also inhibits the release of calcitonin, a hormone which reduces blood calcium primarily by inhibiting calcium release from bone. Calcitriol inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells. Calcitriol increases blood calcium levels ( [Ca2+] ) by promoting absorption of dietary calcium from the gastrointestinal tract and increasing renal tubular reabsorption of calcium thus reducing the loss of calcium in the urine. Calcitriol also stimulates release of calcium from bone by its action on the specific type of bone cells referred to as osteoblasts, causing them to release RANKL, which in turn activates osteoclasts.

*The compound is unstable in solutions, freshly prepared is recommended

Product Citations

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  Int J Oral Sci. 2024 May 22;16(1):41.

  Multiomics profiling reveals VDR as a central regulator of mesenchymal stem cell senescence with a known association with osteoporosis after high-fat diet exposure
  Calcitriol purchased from AbMole

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  J Inflamm Res. 2022 Aug 25;15:4891-4906.

  Vitamin D Ameliorates Apoptosis and Inflammation by Targeting the Mitochondrial and MEK1/2-ERK1/2 Pathways in Hyperoxia-Induced Bronchopulmonary Dysplasia
  Calcitriol purchased from AbMole

Chemical Information

Molecular Weight	416.64
Formula	C27H44O3
CAS Number	32222-06-3
Solubility (25°C)	DMSO 96 mg/mL
Storage	-20°C, protect from light, dry, sealed

References

[1] Jinhui Hu, et al. J Inflamm Res . Vitamin D Ameliorates Apoptosis and Inflammation by Targeting the Mitochondrial and MEK1/2-ERK1/2 Pathways in Hyperoxia-Induced Bronchopulmonary Dysplasia

[2] Beer TM, et al. Mol Cancer Ther. Calcitriol in cancer treatment: from the lab to the clinic.

[3] Canalejo A, et al. J Am Soc Nephrol. The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis.