HY-17506A-50mg | Azithromycin (hydrate) [117772-70-0] Quimigen Portugal

Azithromycin hydrate (Synonyms: CP-62993 dihydrate)

Cat. No.: HY-17506A Pureté: ≥98.0%: FAQs
Fiche technique SDS COA Instruction de manipulation

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Azithromycin hydrate is a macrolide antibiotic useful for the treatment of a number of bacterial infections.

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Azithromycin hydrate Chemical Structure

CAS No. : 117772-70-0

Size	Prix	Stock	Quantité
Échantillon gratuit (0.1 - 0.5 mg)		Appliquer maintenant
50 mg	USD 66	En stock	Estimated Time of Arrival: December 31
100 mg	USD 99	En stock	Estimated Time of Arrival: December 31
200 mg	USD 154	En stock	Estimated Time of Arrival: December 31
500 mg	USD 264	En stock	Estimated Time of Arrival: December 31
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Based on 21 publication(s) in Google Scholar

Other Forms of Azithromycin hydrate:

Azithromycin In-stock
Azithromycin-d₃ In-stock

21 Publications Citing Use of MCE Azithromycin hydrate

Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

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Description

Azithromycin hydrate is a macrolide antibiotic useful for the treatment of a number of bacterial infections.

IC₅₀ & Target

Macrolide

In Vitro

Azithromycin (2 μM) augments rhinovirus-induced IFNβ expression in primary bronchial epithelial cells from asthmatics, which is associated with over-expression of RIG-I like receptors and repression of viral replication. Knockdown of MDA5, but not knockdown of RIG-I, diminishes azithromycin (2 μM)-enhanced viral-induced IFNβ expression in asthmatic primary bronchial epithelial cells^[1]. Azithromycin specifically reduces MMP-9 mRNA and protein levels without affecting NF-κB in endotoxin-challenged monocytic THP-1 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Azithromycin (50 mg/kg) has no effect on bronchoalveolar lavage inflammatory parameters and LDH levels in a mouse model of asthma exacerbation. Azithromycin induces neither general inflammatory parameters nor LDH release in a mouse model of asthma exacerbation, and augments expression of interferon-stimulated genes and the pattern recognition receptor MDA5 but not RIG-I in exacerbating mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Essai clinique

Masse moléculaire

785.02

Formule

C₃₈H₇₆N₂O₁₄

CAS No.

117772-70-0

Appearance

Solid

Color

White to off-white

SMILES

C[C@@H]([C@@H]([C@@](C(O[C@@H]([C@@](C)(O)[C@@H]1O)CC)=O)(06)C)O[C@@](O[C@@H](C)[C@@H]2O)(06)C[C@@]2(C)OC)[C@H]([C@](O)(C[C@H](CN([C@@H]1C)C)C)C)O[C@@](O[C@H](C)C[C@@H]3N(C)C)(06)[C@@H]3O.O.O

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (127.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2739 mL	6.3693 mL	12.7385 mL
5 mM	0.2548 mL	1.2739 mL	2.5477 mL
10 mM	0.1274 mL	0.6369 mL	1.2739 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Pureté et documentation

Purity: ≥98.0%

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Fiche technique (282 KB) SDS (393 KB)

COA (260 KB) HNMR (303 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Menzel M, et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017 Mar 18. [Content Brief]

[2]. Vandooren J, et al. Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study. PLoS One. 2017 Apr 3;12(4):e0174853. [Content Brief]

Test cellulaire ^[2]	THP-1 cells (10⁶ cells in 1 mL RPMI medium, without antibiotics, growth factors or serum) are seeded in each well of 24-well plates and allowed to settle for 1 hour. Next, 50 μL of the test compound is added followed by 50 μL of LPS (final concentration of 10 μg/mL). After 24h (37°C and 5% CO₂) the supernatants and cell pellets are collected (1200 rpm, 5 min). THP-1 cell viability is tested using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). MTT is dissolved at 2 mg/mL in PBS and aliquots are stored at -20°C. The MTT assay is performed according to the suppliers instructions. Absorbance of MTT converted into formazan is measured at a wavelength of 570 nm with background subtraction at 630 nm. MCE n'a pas confirmé de manière indépendante l'exactitude de ces méthodes. Ils sont pour référence seulement.
Références	[1]. Menzel M, et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017 Mar 18. [Content Brief] [2]. Vandooren J, et al. Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study. PLoS One. 2017 Apr 3;12(4):e0174853. [Content Brief]

Test cellulaire
^[2]

THP-1 cells (10⁶ cells in 1 mL RPMI medium, without antibiotics, growth factors or serum) are seeded in each well of 24-well plates and allowed to settle for 1 hour. Next, 50 μL of the test compound is added followed by 50 μL of LPS (final concentration of 10 μg/mL). After 24h (37°C and 5% CO₂) the supernatants and cell pellets are collected (1200 rpm, 5 min). THP-1 cell viability is tested using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). MTT is dissolved at 2 mg/mL in PBS and aliquots are stored at -20°C. The MTT assay is performed according to the suppliers instructions. Absorbance of MTT converted into formazan is measured at a wavelength of 570 nm with background subtraction at 630 nm.

MCE n'a pas confirmé de manière indépendante l'exactitude de ces méthodes. Ils sont pour référence seulement.

Références

[1]. Menzel M, et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017 Mar 18. [Content Brief]

[2]. Vandooren J, et al. Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study. PLoS One. 2017 Apr 3;12(4):e0174853. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2739 mL	6.3693 mL	12.7385 mL	31.8463 mL
	5 mM	0.2548 mL	1.2739 mL	2.5477 mL	6.3693 mL
	10 mM	0.1274 mL	0.6369 mL	1.2739 mL	3.1846 mL
	15 mM	0.0849 mL	0.4246 mL	0.8492 mL	2.1231 mL
	20 mM	0.0637 mL	0.3185 mL	0.6369 mL	1.5923 mL
	25 mM	0.0510 mL	0.2548 mL	0.5095 mL	1.2739 mL
	30 mM	0.0425 mL	0.2123 mL	0.4246 mL	1.0615 mL
	40 mM	0.0318 mL	0.1592 mL	0.3185 mL	0.7962 mL
	50 mM	0.0255 mL	0.1274 mL	0.2548 mL	0.6369 mL
	60 mM	0.0212 mL	0.1062 mL	0.2123 mL	0.5308 mL
	80 mM	0.0159 mL	0.0796 mL	0.1592 mL	0.3981 mL
	100 mM	0.0127 mL	0.0637 mL	0.1274 mL	0.3185 mL

Azithromycin hydrate Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azithromycin117772-70-0CP-62993 dihydrateBacterialAutophagyAntibioticParasiteInhibitorinhibitorinhibit

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Azithromycin (hydrate) [117772-70-0]

Referência HY-17506A-50mg

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Marca : MedChemExpress

Contactar o distribuidor local :

Azithromycin hydrate (Synonyms: CP-62993 dihydrate)

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Other Forms of Azithromycin hydrate:

21 Publications Citing Use of MCE Azithromycin hydrate

Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform Antibiotic:

Voir tous les produits spécifiques à Isoform Parasite:

Activité biologique

Protocole

Pureté et documentation

Références

Avis client

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Calculateur de dilution

Complete Stock Solution Preparation Table

Azithromycin hydrate Related Classifications

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Azithromycin (hydrate) [117772-70-0]

Referência HY-17506A-50mg

Contactar o distribuidor local :

Marca : MedChemExpress

Contactar o distribuidor local :

Azithromycin hydrate (Synonyms: CP-62993 dihydrate)

Avis client

Other Forms of Azithromycin hydrate:

Azithromycin hydrate Related Antibodies

21 Publications Citing Use of MCE Azithromycin hydrate

Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform Antibiotic:

Voir tous les produits spécifiques à Isoform Parasite:

Activité biologique

Protocole

Pureté et documentation

Références

Avis client

Azithromycin hydrate Related Antibodies

Calculateur de molarité

Calculateur de dilution

Complete Stock Solution Preparation Table

Azithromycin hydrate Related Classifications

Keywords:

Vos produits récemment consultés:

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