| Short Description : | Rabbit polyclonal antibody anti-Phospho-PDE3B (260-310) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Applications: | ELISA/IP/WB |
| Host: | Rabbit |
| Reactivity: | Chicken/Human/Monkey/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Biotin |
| Concentration: | 0.70 µg/µl |
| Purification: | Affinity Purified |
| Dilution Range: | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000 |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
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| Immunogen: | Synthetic peptide taken within amino acid region 260-310 on human PDE3B protein. Selective only for PDE3B variant. |
| Immunogen Region: | 260-310 |
| Tissue Specificity | Abundant in adipose tissues. |
| Post Translational Modifications | Phosphorylation at Ser-295 mediates insulin-induced activation of PDE3B. |
| Function | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process. Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling. Controls cardiac contractility by reducing cAMP concentration in cardiocytes. |
| Protein Name | Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3bCgipde1Cgip1Cyclic Gmp-Inhibited Phosphodiesterase BCgi-Pde B |
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| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3b antibodyAnti-Cgipde1 antibodyAnti-Cgip1 antibodyAnti-Cyclic Gmp-Inhibited Phosphodiesterase B antibodyAnti-Cgi-Pde B antibodyAnti-PDE3B antibody |
Information sourced from Uniprot.org