Anti-CD21 Monoclonal Antibody (Clone:LT21)-PE Conjugated
Figure 1: Surface staining of human peripheral blood leukocytes with anti-CD21 (LT21) PE.
| Amount : | 100 tests |
| Isotype : | Mouse IgG1 kappa |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.
| Subcellular location: | Membrane |
| Tissue Specificity: | Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen. |
| BioGrid: | 107771. 7 interactions. |
| There are currently no product reviews |