TSHR antibody - N-terminal region
Referencia ARP41870_T100
embalaje : 100ul
Marca : Aviva Systems Biology
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TSHR Antibody - N-terminal region (ARP41870_T100)
| Datasheets/Manuals | Printable datasheet for anti-TSHR (ARP41870_T100) antibody |
|---|
| Tested Species Reactivity | Human |
|---|---|
| Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Sheep |
| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Application | WB |
| Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human TSHR |
| Purification | Protein A purified |
| Predicted Homology Based on Immunogen Sequence | Cow: 93%; Dog: 86%; Horse: 86%; Human: 100%; Mouse: 79%; Rabbit: 77%; Rat: 79%; Sheep: 100% |
| Peptide Sequence | Synthetic peptide located within the following region: CHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISR |
| Concentration | 1.0 mg/ml |
| Blocking Peptide | For anti-TSHR (ARP41870_T100) antibody is Catalog # AAP41870 (Previous Catalog # AAPP24407) |
| Sample Type Confirmation | There is BioGPS gene expression data showing that TSHR is expressed in Jurkat |
| Enhanced Validation | Relative Expression (Western Blot)  |
| Reference | Claus,M., (2005) Endocrinology 146 (12), 5197-5203 |
|---|---|
| Gene Symbol | TSHR |
| Gene Full Name | Thyroid stimulating hormone receptor |
| Alias Symbols | LGR3, CHNG1, hTSHR-I |
| NCBI Gene Id | 7253 |
| Protein Name | Thyrotropin receptor |
| Description of Target | TSHR is receptor for thyrothropin. It plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. It also acts as a receptor for thyrostimulin (GPA2+GPB5). |
| Uniprot ID | Q96GT6 |
| Protein Accession # | NP_001018046 |
| Nucleotide Accession # | NM_001018036 |
| Protein Size (# AA) | 764 |
| Molecular Weight | 87 kDa |
| Protein Interactions | ADRB2; SCRIB; UBC; TSHB; RABAC1; GNA13; GNA12; FLNB; TSHR; GNAQ; PIK3R1; LHCGR; JAK2; JAK1; GNAI3; GNAI2; GNAS; GNA11; GNAO1; GNAI1; HSPA5; FN1; CANX; CALR; STAT3; CALCR; |
