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> Trilaurin [538-24-9]

Trilaurin [538-24-9]

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Referencia HY-126573-500mg

embalaje : 500mg

Marca : MedChemExpress

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Descripciòn

Trilaurin is an orally active triglyceride. Trilaurin inhibits DMBA-induced, croton oil-promoted skin tumor formation in Swiss Webster mice. Trilaurin increases plasma high-density lipoprotein cholesterol and apolipoprotein A-I concentrations. Trilaurin is used as an occlusive skin conditioning agent and/or non-aqueous thickener in cosmetics[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Trilaurin does not inhibit 5α-reductase activity in prostate tissue samples[1].
Trilaurin (4 mg per plate) shows no mutagenicity in *Salmonella typhimurium* strains TA1535, TA100, TA1537, TA1538, or TA98 with or without metabolic activation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Trilaurin Related Antibodies
In Vivo

Trilaurin (6.5% w/w; oral administration; mixed into feed; 4 days, 1 week) increases plasma HDL cholesterol and apolipoprotein A-I (apo A-I) concentrations in WHHL rabbits and NZW rabbits, and this effect is reversible after discontinuation[1].
Trilaurin (3 times per week; for 20 weeks) completely inhibits DMBA-induced, croton oil-promoted skin tumor formation in Swiss Webster mice[1].
Trilaurin (25% w/w; p.o.; mixed into feed; daily; 10 weeks) exerts no toxic effects or induces no body weight changes in weanling rats[1].
Trilaurin (accounting for 36.3% w/w; administered via topical ocular instillation, 3 times) causes mild irritation in rabbits, with a Draize score of 2[1].
Trilaurin (36.3% w/w; administered percutaneously; delivered via occlusive patch) causes no skin irritation in rabbits[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Watanabe (WHHL) rabbits (6 months old); New Zealand white (NZW) rabbits (10 months old)[1]
Dosage: 6.5% w/w
Administration: oral; mixed in chow diet; 4 days, 1 week
Result: Increased plasma HDL cholesterol to 250% of baseline and apo A-I to 200% of baseline in 6-month-old WHHL rabbits.
Returned both parameters to baseline after Trilaurin was removed.
Produced similar increases in 10-month-old WHHL and NZW rabbits after 1 week of supplementation.
Animal Model: Rabbits[1]
Dosage: 36.3% w/w
Administration: ocular instillation; three times
Result: Produced a Draize score of 2, classified as mildly irritating to rabbit eyes.
Animal Model: Rabbits[1]
Dosage: 36.3% w/w
Administration: topical; occlusive patch application
Result: Observed no erythema or edema in any rabbits at 2 or 24 hours after patch removal, classifying the test substance as nonirritating to rabbit skin.
Peso molecular

639.00

Fòrmula

C39H74O6
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCC(OCC(OC(CCCCCCCCCCC)=O)COC(CCCCCCCCCCC)=O)=O
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 4 mg/mL (6.26 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : 1 mg/mL (1.56 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5649 mL 7.8247 mL 15.6495 mL
5 mM 0.3130 mL 1.5649 mL 3.1299 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias