embalaje : 25mg
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Synonyms: Trigenolline
| Description | Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. |
| In vitro | Treatment of cells with Trigonelline attenuates H2O2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline regulates the apoptotic gene caspase-3, caspase-9, and anti-apoptotic gene Bcl-2, Bcl-XL during H2O2 induced oxidative stress in H9c2 cells. Trigonelline significantly reduces the H2O2 induced necrosis and apoptosis in H9c2 cells. However, the further increment of Trigonelline concentration against H2O2 can induce the necrosis and apoptosis along with H2O2[1]. |
| In vivo | Trigonelline decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. Trigonelline significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength in nicotinamide/streptozotocin-treated rats. Trigonelline differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders like intensify the osteoporotic changes in streptozotocin-treated rats and favorably affect bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats[2]. |
| Synonyms | Trigenolline |
| Molecular Weight | 137.14 |
| Formula | C7H7NO2 |
| Cas No. | 535-83-1 |
| Smiles | C[n+]1cccc(c1)C([O-])=O |
| Relative Density. | 1.2528 g/cm3 (Estimated) |
| Storage | Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 27.78 mg/mL (202.57 mM), Sonication is recommended.  DMSO: 7.5 mg/mL (54.69 mM), Sonication is recommended. Ethanol: Insoluble | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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