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TMBIM6 Protein Lysate

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Referencia OCOA13746

embalaje : 20µg

Marca : Aviva Systems Biology

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TMBIM6 Protein Lysate (OCOA13746)

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TMBIM6 Protein Lysate (OCOA13746)
Datasheets/ManualsPrintable datasheet for TMBIM6 Protein Lysate (OCOA13746)
Product Info
Predicted Species ReactivityHomo sapiens
Product FormatLyophilized
HostHEK293T
Additional InformationComponents: 1 vial of 20 ug lyophilized gene specific transient over-expression cell lysate
::Preparation: HEK293T cells in 10-cm dishes were transiently transfected with MegaTran Transfection Reagent and 5ug TrueORF cDNA plasmid. Transfected cells were cultured for 48hrs before collection. The cells were lysed in modified RIPA buffer (25mM Tris-HCl pH7.6, 150mM NaCl, 1% NP-40, 1mM EDTA, 1xProteinase inhibitor cocktail mix (Sigma), 1mM PMSF and 1mM Na3VO4), and then centrifuged to clarify the lysate. Protein concentration was measured by BCA kit (Thermo Scientific Inc.). To facilitate transportation and protein, the products are supplied as lyophilized proteins.
Reconstitution and Storage2°C to 8°C
TagC-MYC/DDK
Gene SymbolTMBIM6
Gene Full Nametransmembrane BAX inhibitor motif containing 6
Alias Symbolsbax inhibitor 1, BAXI1, BI-1, TEGT, testis enhanced gene transcript, testis-enhanced gene transcript protein, transmembrane BAX inhibitor motif-containing protein 6.
NCBI Gene Id7009
Protein NameBax inhibitor 1|bax inhibitor 1 isoform 1 [Homo sapiens]|Homo sapiens transmembrane BAX inhibitor motif containing 6 (TMBIM6), transcript variant 1, mRNA
Description of TargetSuppressor of apoptosis (PubMed:21075086). Modulates unfolded protein response signaling (PubMed:21075086). Modulates ER calcium homeostasis by acting as a calcium-leak channel (PubMed:22128171). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity).
Uniprot IDP55061
Protein Accession #https://www.ncbi.nlm.nih.gov/protein/NP_003208
Nucleotide Accession #https://www.ncbi.nlm.nih.gov/nuccore/NM_003217
Molecular Weight26.4 kDa