TET3 Antibody
Referencia OAGA08291
embalaje : 100ul
Marca : Aviva Systems Biology
Contact local distributor :
Teléfono : +1 850 650 7790
| Datasheets/Manuals | Printable datasheet for TET3 Antibody (OAGA08291) |
|---|
| Predicted Species Reactivity | Human |
|---|---|
| Product Format | Liquid |
| Clonality | Monoclonal |
| Clone | GT334 |
| Isotype | IgG2b |
| Host | Mouse |
| Conjugation | Unconjugated |
| Application | WB |
| Reconstitution and Storage | -20°C or -80°C|2°C to 8°C |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human TET3. The exact sequence is proprietary. |
| Purification | Protein G Purified |
| Concentration | 1 mg/ml |
| Application Info | Suggested starting dilutions are as follows: WB: 1:1000-1:10000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user. |
| Storage Buffer | PBS |
| Gene Symbol | TET3 |
|---|---|
| Gene Full Name | tet methylcytosine dioxygenase 3 |
| Alias Symbols | BEFAHRS, hCG_40738, methylcytosine dioxygenase TET3, probable methylcytosine dioxygenase TET3, putative methylcytosine dioxygenase, ten-eleven translocation 3, tet oncogene family member 3. |
| NCBI Gene Id | 200424 |
| Protein Name | Methylcytosine dioxygenase TET3 |
| Description of Target | Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation (By similarity). Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes (PubMed:23217707). In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT (PubMed:23353889). |
| Uniprot ID | O43151 |
| Protein Accession # | NP_001274420.1 |
| Nucleotide Accession # | NM_001287491.1 |
