Rutaecarpine [84-26-4]
Referencia NB-64-18598-500mg
embalaje : 500mg
Marca : Neo Biotech
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Teléfono : +1 850 650 7790
Rutaecarpine (Synonyms: Rutecarpine, Rutacarpine, Rhetine)
Catalog No. T2972 Copy Product Info
Purity: 99.2%
Rutaecarpine (Rhetine) is an inhibitor of COX-2 with IC50 of 0.28 μM.
Rutaecarpine
Copy Product InfoSynonyms Rutecarpine, Rutacarpine, Rhetine
Rutaecarpine (Rhetine) is an inhibitor of COX-2 with IC50 of 0.28 μM.
Cas No. 84-26-4
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Rutaecarpine (Rhetine) is an inhibitor of COX-2 with IC50 of 0.28 μM. |
| Targets&IC50 | COX-1:8.7 μM (in BMMC), COX-2:0.28 μM |
| In vitro | Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs, which has shown a variety of intriguing biological properties such as anti-thrombotic, anticancer, anti-inflammatory and analgesic, anti-obesity and thermoregulatory, vasorelaxing activity, as well as effects on the cardiovascular and endocrine systems. [1] |
| Cell Research | Rutaecarpine is dissolved in DMSO and diluted with appropriate medium before use. COX-1 and COX-2 cDNA-transfected HEK293 cells are prepared. For measuring inhibitory activity on COX-1 and COX-2 by rutaecarpine, cells in 1 mL of culture medium are seeded into each well of 24-well. After culture for 4 days, the supernatants are removed and 250 mL of fresh medium is added to the cells with or without rutaecarpine. After preincubation for 5 h at 37°C, the cells are further incubated at 37°C for 30 min with 50 mM arachidonic acid. All reactions are stopped by centrifugation at 120 g at 4°C for 5 min. Concentrations of PGE2 in the supernatant are measured[1]. |
| Synonyms | Rutecarpine, Rutacarpine, Rhetine |
| Molecular Weight | 287.32 |
| Formula | C18H13N3O |
| Cas No. | 84-26-4 |
| Smiles | O=C1N2CCC3=C(NC4=CC=CC=C34)C2=NC2=CC=CC=C12 |
| Relative Density. | 1.45 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 0.3 mg/mL (1.04 mM)  DMSO: 50 mg/mL (174.02 mM), Sonication is recommended. H2O: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||||||||||||||||||||||
| In Vivo Formulation | PBS: < 1 mg/mL (insoluble) Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||||||||||||