1. Intermedin1-53 may attenuate vascular calcification by upregulating alpha-Klotho via the calcitonin receptor/modifying protein complex and protein kinase A signaling.
2. The antiaging protein klotho inhibits angiotensin II -induced cardiomyocyte hypertrophy.
3. The results suggested that the cardioprotective effects of klotho were related to the attenuation of oxidative stress, and oxidative stress suppressed the transcription of klotho
4. klotho is involved in the maintenance of baroreflex sensitivity in the brain.
5. Klotho gene delivery abolished the upregulation of endothelin-1 levels and the downregulation of ETB and Mn-SOD expression in kidneys of spontaneously hypertensive rats
6. Klotho attenuates high glucose-induced fibronectin expression and cell hypertrophy via the ERK1/2 and p38 kinase-dependent pathways.
7. Klotho protects the kidney against cisplatin nephrotoxicity by reduction of basolateral uptake of cisplatin by OCT2 and a direct anti-apoptotic effect independent of cisplatin uptake.
8. These results provide the first anatomical localization of klotho mRNA and protein in rat brain parenchyma and demonstrate that klotho levels vary during early postnatal development.
9. Silencing of brain klotho potentiated and expedited cold-induced elevation of blood pressure by upregulation of endothelin-1 and the subsequent activation of the sympathetic nervous system.
10. the therapeutic potential of soluble Klotho protein to treat age-related disorders in mice
11. These results suggest that the expression of Klotho is regulated by the balance between upregulation and downregulation of Wnt signaling.
12. The Klotho gene can attenuate the progression of hypertension and abolishes myocardial hypertrophy and myocardial fibrosis.
13. these studies provide novel evidence for Klotho as a key player in myelin biology, which may thus be a useful therapeutic target in efforts to protect brain myelin against age-dependent changes and promote repair in multiple sclerosis.
14. Aging-related kidney damage is associated with a decrease in klotho expression
15. Renal mRNA and protein expression of Klotho plays important an role in progression of hypertensive renal damage in spontaneously hypertensive rats.
16. Fosinopril up-regulates klotho mRNA in time-dependent manner, and inhibits the down-regulated expression of klotho gene induced by Ang II.
17. Fosinopril and losartan can exert protection against hypertensive renal damage through upregulating Klotho expression as well as reducing oxidative stress.
18. New insights into the pathology of age-related degeneration of dopaminergic neurons are possibly related to Klotho-mediated regulation of vitamin D.
19. Valsartan can improve the brain ultrastructure of spontaneously hypertensive rats by increasing the expression of Klotho.
20. Suggest that klotho may act as a positive regulator of parathyroid hormone expression and secretion in secondary hyperparathyroidism.
21. Decrease of oxidative stress is not only responsible for the improvement of renal function but also for the recovery of Klotho expression in kidney of streptozotocin-induced diabetic rats.
22. AST-120 increases Klotho expression, and inhibited cell senescence in the kidney of CRF rats, probably by alleviating indoxyl sulfate overload on the kidney
23. klotho distribution & expression in rat models of insulin resistance; no significant differences between insulin resistant and control animals; conclude that decreased klotho expression is not a general feature of rodent models of insulin resistance
24. Klotho is post-translationally processed and there are regulatory mechanisms for its secretion in vivo
25. Insulin enhances KL shedding without increasing ADAM10 and ADAM17 mRNA and protein levels
26. Klotho may have a broader function in the regulation of ion transport in the kidney.
27. Klotho may have a role in the modulation of endothelial inflammation.

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