Poloxamer 188 [691397-13-4]
Referencia NB-64-78894-50mg
embalaje : 50mg
Marca : Neo Biotech
Contact local distributor :
Teléfono : +1 850 650 7790
Poloxamer 188
Catalog No. T40802 Copy Product Info
Poloxamer 188 is a nonionic triblock copolymer surfactant and bioactive excipient used as a medical excipient to exacerbate cerebral amyloidosis, presynaptic dystrophy, and pathogenic microglial cell activation in 5XFAD mice.
Poloxamer 188
Copy Product InfoPoloxamer 188 is a nonionic triblock copolymer surfactant and bioactive excipient used as a medical excipient to exacerbate cerebral amyloidosis, presynaptic dystrophy, and pathogenic microglial cell activation in 5XFAD mice.
Cas No. 691397-13-4
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Poloxamer 188 is a nonionic triblock copolymer surfactant and bioactive excipient used as a medical excipient to exacerbate cerebral amyloidosis, presynaptic dystrophy, and pathogenic microglial cell activation in 5XFAD mice. |
| In vitro | Poloxamer 188 exhibited a protective effect on mouse brain microvascular endothelial cells (MBEC) after treatment in the concentration range of 10-1000 μM for 5 hours. In addition, Docetaxel-loaded PLGA/Poloxamer 188 nanoparticles significantly increased drug uptake levels and cytotoxicity in Docetaxel-resistant MCF-7 TAX30 human breast cancer cells compared to Docetaxel-loaded PLGA nanoparticles. [1][2] |
| In vivo | Poloxamer 188 administered intravenously at a dose of 150 mg/kg over 240 minutes significantly reduced muscle edema and lipid peroxidation induced by ischemia-reperfusion. [3] |
| Cas No. | 691397-13-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |