Ovotransferrin Antibody, HRP conjugated
Referencia CSB-PA00390F0Rb-100ug
embalaje : 100ug
Marca : Cusabio
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Product Details
Uniprot No.
Alternative Names
Ovotransferrin antibody; Allergen Gal d III antibody; Conalbumin antibody; Serum transferrin antibody; allergen Gal d 3 antibody
Raised in
Rabbit
Species Reactivity
Chicken
Immunogen
Chicken Ovotransferrin (Native Protein)
Immunogen Species
Chicken
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Customer Reviews and Q&A
There are currently no reviews for this product.
Target Background
Function
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. There are two forms of hen transferrin, ovotransferrin, found in the ovoducts and, serum transferrin, secreted by the liver. Serum transferrin may also have a role in stimulating cell proliferation and is regulated by iron levels. Ovotransferrin has a bacteriostatic function and, is not controlled by iron levels.
Gene References into Functions
- unfolding pathway and conformational stability of conalbumin
- glycosylation of fetal & hen ovotransferrin differs; hypothesized to alter ovotransferrin recognition by carbohydrate binding lectins
- studied the carbohydrate and amino acid compositions of the ovotransferrin glycopeptides
- The exon structure of the ovotransferrin gene confirms the duplication event to produce two homologous domains that make up ovotransferrin
- evidence suggests that conalbumin (ovotransferrin) and transferrin are products of the same gene, differing only in carbohydrate content
- show both lobes are required for efficient iron binding and calculate binding kinetics.
- ovotransferrin folds into two compact, iron-binding domains; the authors demonstrate that the duplicated domain structure is necessary to retain ovotransferrin in plasma and stop immediate loss via kidney filtration
- The structure of ovotransferrin shows that the iron-binding site is located in the interdomain cleft in each lobe; differences in ovotransferrin structure cause changes to iron binding & uptake/release compared to lactotransferrin & transferrin.
- At a pH where the protein net charge is negative (pH 8.0), the behavior of ovotransferrin at the air-water interface is more influenced by charge effects rather than bulk concentration effects.
- Trp-Asn-Ile-Pro and Gly-Trp-Asn-Ile peptides of ovotransferrin showed the highest antioxidant activity.
- Marked stabilization effects by amino(N)- and carboxyl(C)-terminal lobes of ovotransferrin are induced during iron binding, primarily upon N-lobe iron binding in the iron-free C-lobe and secondarily upon C-lobe iron binding in the monoferric N-lobe.
- Ovotransferrin is able to cleave itself through the unique chemical reactivity of four tripeptides motifs, HTT (residues 209-211), HST (residues 542-544) and two CHT (residues 115-117 and 454-456).
- Several proteins associated with the egg shell membranes (ESM) with antibacterial activity have been identified including ovotransferrin, in addition, pure fractions of ovotransferrin were obtained from egg white.
Subcellular Location
Secreted.
Protein Families
Transferrin family
Tissue Specificity
Expressed in the magnum of the oviduct (at protein level).
Database Links
KEGG:
UniGene: