embalaje : 1mg
Teléfono : +1 850 650 7790
Synonyms:
| Description | Neuropeptide Y (NPY) is a 36-amino acid neuropeptide that exerts its activity via G-protein-coupled receptors. NPY is widely distributed in the peripheral and central nervous systems. It modulates a variety of physiological processes, e.g. the central regulation of vasoconstriction, memory retention and food intake, and the regulation of circadian rhythm. |
| In vitro | Scrambled NPY peptide treatment had no effect on VEGF expression in 4T1 cells. Previous treatment with scrambled NPY at concentrations ranging from 10?10 to 10?7 M made conditioned media from 4T1 cells show no difference in the number of complete endothelial networks or branch points versus control in endothelial tube formation assays [2][3]. |
| In vivo | In trimethyltin-treated (TMT-treated) rats, treatment with scrambled NPY for 24 h made the expression of Bdnf, NpyR, neurogenic and antiapoptotic genes comparable to that of saline-injected animals (without significant differences). In TMT-treated rats, both saline and scNPY showed no significant modulation (p> 0.05) in the expression levels of Npy1R, Npy2R, and Npy5R [4][5]. |
| Molecular Weight | 4253.7 |
| Formula | C190H287N55O57 |
| Relative Density. | no data available |
| Sequence | Ser-Lys-Pro-Gln-Arg-Asp-Ala-Asn-Arg-Glu-Pro-Thr-Arg-Tyr-Ala-Ile-Tyr-Asp-Tyr-Ser-Asn-Pro-Asp-Ile-Glu-Leu-His-Tyr-Leu-Arg-Pro-Ala-Tyr-Ala-Leu-Gly-NH₂ |
| Sequence Short | SKPQRDANREPTRYAIYDYSNPDIELHYLRPAYALG |
| Storage | Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O: 1 mg/mL (0.24 mM), Sonication is recommended. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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