Naproxen [22204-53-1]
Referencia HY-15030-10g
embalaje : 10g
Marca : MedChemExpress
Para uso exclusivo en investigación. No vendemos a pacientes.
Naproxen Estructura química
No. CAS : 22204-53-1
Tamaño | Precio | Stock | Cantidad |
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Muestra gratis (0.1 - 0.5 mg) | Solicite ahora | ||
Solid + Solvent | |||
10 mM * 1 mL
in DMSO
ready for reconstitution
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USD 55 | En stock | |
Solution | |||
10 mM * 1 mL in DMSO | USD 55 | En stock | |
Solid | |||
500 mg | USD 50 | En stock | |
5 g | USD 60 | En stock | |
10 g | USD 96 | En stock | |
50 g | Obtener un presupuesto |
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This product is a controlled substance and not for sale in your territory.
Based on 2 publication(s) in Google Scholar
Other Forms of Naproxen:
- (±)-Naproxen In-stock
- Naproxen sodium In-stock
2 Publications Citing Use of MCE Naproxen
•Related Screening Libraries:
•Related Small Molecules:
•Related Proteins:
Ver todos los productos específicos de isoformas COX:
Actividad biológica
Protocolo
Pureza y Documentación
Referencias
Revisión del cliente
Descripciòn | |||||||||||||
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IC50 & Target[1] |
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In Vitro |
Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50s of 2.2 μg/mL and 1.3 μg/mL, respectively[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation[2]. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC50=27, 40, 13 μM)[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Ensayo clínico |
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Peso molecular |
230.26 |
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Fòrmula |
C14H14O3 |
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No. CAS | |||||||||||||
Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
C[C@H](C(O)=O)C1=CC2=CC=C(OC)C=C2C=C1 |
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Envío | Room temperature in continental US; may vary elsewhere. |
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Almacenamiento |
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Solvente y solubilidad |
In Vitro:
DMSO : ≥ 100 mg/mL (434.29 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : 75 mg/mL (325.72 mM; Need ultrasonic and warming) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Pureza y Documentación |
Purity: 99.99% |
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Referencias |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O / DMSO | 1 mM | 4.3429 mL | 21.7146 mL | 43.4292 mL | 108.5729 mL |
5 mM | 0.8686 mL | 4.3429 mL | 8.6858 mL | 21.7146 mL | |
10 mM | 0.4343 mL | 2.1715 mL | 4.3429 mL | 10.8573 mL | |
15 mM | 0.2895 mL | 1.4476 mL | 2.8953 mL | 7.2382 mL | |
20 mM | 0.2171 mL | 1.0857 mL | 2.1715 mL | 5.4286 mL | |
25 mM | 0.1737 mL | 0.8686 mL | 1.7372 mL | 4.3429 mL | |
30 mM | 0.1448 mL | 0.7238 mL | 1.4476 mL | 3.6191 mL | |
40 mM | 0.1086 mL | 0.5429 mL | 1.0857 mL | 2.7143 mL | |
50 mM | 0.0869 mL | 0.4343 mL | 0.8686 mL | 2.1715 mL | |
60 mM | 0.0724 mL | 0.3619 mL | 0.7238 mL | 1.8095 mL | |
80 mM | 0.0543 mL | 0.2714 mL | 0.5429 mL | 1.3572 mL | |
100 mM | 0.0434 mL | 0.2171 mL | 0.4343 mL | 1.0857 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Naproxen Related Classifications
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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
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Inquiry Information
- Nombre del producto:
- Naproxen
- Cat. No.:
- HY-15030
- Cantidad:
- MCE Japan Authorized Agent: