Mouse Monoclonal Anti-Involucrin (Squamous Cell Terminal Differentiation Marker) (Clone IVRN/827)
Referencia 24-3713-MSM2-500ul
embalaje : 500ul
Marca : American Research Products
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Teléfono : +1 850 650 7790
Anti-Involucrin (Squamous Cell Terminal Differentiation Marker), Monoclonal Antibody
Category: Antibodies
Catalog
24-3713-MSM2
| Product Name | Anti-Involucrin (Squamous Cell Terminal Differentiation Marker), Monoclonal Antibody |
|---|---|
| Description | It recognizes a protein of 66kDa-170kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this monoclonal antibody reacts with a 120kDa protein. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal; expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix. |
| Synonyms | IVL |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | IVRN/827 |
| Immunogen | Purified involucrin from human keratinocytes |
| Isotype | IgG1, kappa |
| Reactivity | Human |
| Applications | FC, IF, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 3713 |
| Uniprot | P07476 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Eckert, R.L. and Green, H. 1986. Structure and evolution of the human involucrin gene. Cell 46: 583-589 |
| Supplier | ARP |
View product citations for antibody 24-3713-MSM2 on CiteAb